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Amino acid transmitters in the mammalian central nervous system.
2. Evidence for A m i n o Acids as T ransmi t t e r s . . . . . . . . . . . . . . . . . . . . 99 2.1. Synthesis and Storage . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 2.2. Synapt ic… Expand
The interpretation of spike potentials of motoneurones
Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat.
Summary (1) A study has been made of the effects of bicuculline, a phthalide isoquinoline convulsant alkaloid, on the inhibition of spinal neurones by amino acids and the synaptic inhibition of… Expand
Synaptic action during and after repetitive stimulation
GABA, Bicuculline and Central Inhibition
The central nervous action of the alkaloid bicuculline provides pharmacological evidence that GABA is likely to be a transmitter at certain inhibitory synapses.
The chemical excitation of spinal neurones by certain acidic amino acids
The presence of comparatively large quantities of glutamic acid in nervous tissue has led to speculation concerning its function therein (Waelsch, 1955). Hitherto metabolic aspects have been… Expand
The generation of impulses in motoneurones
It has been shown that the intracellularly recorded spike potential of motoneurones is compounded of three separate responses, each normally having an all-or-nothing character: the M spike of the… Expand
Chemical Excitation of Spinal Neurones
THE presence of comparatively large quantities of glutamic acid in brain together with the conflicting evidence of the effects of glutamic acid administration1 have led to an investigation of the… Expand
THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS
THE anions of aspartic and glutamic acids have potent excitatory action upon spinal neurones (CURTIS, PHILLIS and WATKINS, 1960); this is in marked contrast to the strongly depressant action… Expand
New class of glutamate agonist structurally related to ibotenic acid
- P. Krogsgaard‐Larsen, T. Honoré, J. Hansen, D. R. Curtis, D. Lodge
- Chemistry, Medicine
- 6 March 1980
L-Glutamic acid (Glu) and L-aspartic acid (Asp) are putative excitatory transmitters in the mammalian central nervous system (CNS)1–3. Receptors at Glu- and Asp-mediated synapses are presumably… Expand