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Tridemethylisovelleral, a potent cytotoxic agent.
- I. Aujard, D. Röme, E. Arzel, M. Johansson, D. de Vos,, O. Sterner
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 November 2005
The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the… Expand
Derivatization using dimethylamine for tandem mass spectrometric structure analysis of enzymatically and acidically depolymerized methyl cellulose.
- D. Momcilovic, H. Schagerlöf, +6 authors G. Brinkmalm
- Chemistry, Medicine
- Analytical chemistry
- 1 May 2005
The combination of DMA derivatization and tandem MS was demonstrated as a tool for the characterization of endoglucanase selectivity and introduced a basic functional group that increased the sensitivity in both MALDI and nano-ESI. Expand
Enantioselective formal synthesis of tridemethylisovelleral
A simple and efficient synthetic route to the bicyclic α,β-unsaturated β-keto ester methyl (3aS,7aS)-6-oxo-2,3,3a,6,7,7a-hexahydro-1H-indene-5-carboxylate, a versatile intermediate in the synthesis… Expand
Synthesis of Bioactive Analogues of Marasmane Dialdehydes
- D. Röme
The modification of drugs into pro-drugs is an attractive concept allowing you to tweak the chemical and physical properties of a drug without changing the original structure of the active compound.… Expand
Synthesis of biomimetic precursors of isovelleral analogues.
Based on how the mushroom Lactarius vellereus converts an inactive precursor into the cytotoxic dialdehyde isovelleral (1) via a cyclic enol ether, as part of a binary chemical defense system that… Expand
Process for the production of (ethyne-1,2-diyl) bis (isobenzofuran-1,3-dione)
Process for (ethyne-1,2-diyl) bis (isobenzofuran-1,3-dione), comprising the steps of: - reacting an chloro-, bromo-, or iodo-isobenzofuran-1,3-dione ethyne in an aprotic solvent and in the presence… Expand
Synthesis of Decaline Analogues of Isovelleral
Decaline analogues of the bioactive fungal sesquiterpene (+)-isovelleral (1a), retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system, were prepared, and their cytotoxic and antimicrobial… Expand