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Enabling factors related to prosthetic use by people with transtibial and transfemoral amputation.
- C. Gauthier-Gagnon, M. Grise, D. Potvin
- Archives of physical medicine and rehabilitation
- 1 June 1999
OBJECTIVE To evaluate the frequency and extent of prosthetic use by people with lower limb amputation and identify factors that facilitate prosthetic use. DESIGN AND SETTING Five-year follow-up… Expand
Sequential design approaches for bioequivalence studies with crossover designs.
- D. Potvin, C. Diliberti, W. Hauck, A. Parr, Donald J. Schuirmann, R. Smith
- Psychology, Medicine
- Pharmaceutical statistics
- 1 October 2008
The planning of bioequivalence (BE) studies, as for any clinical trial, requires a priori specification of an effect size for the determination of power and an assumption about the variance. The… Expand
Metabolic effects of a growth hormone-releasing factor in patients with HIV.
- J. Falutz, S. Allas, +9 authors S. Grinspoon
- The New England journal of medicine
- 6 December 2007
BACKGROUND Visceral adipose tissue accumulates during antiretroviral therapy in many patients who are infected with the human immunodeficiency virus (HIV); this process is associated with an… Expand
Effects of Tesamorelin, a Growth Hormone–Releasing Factor, in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial With a Safety Extension
- J. Falutz, D. Potvin, +10 authors S. Grinspoon
- Journal of acquired immune deficiency syndromes
- 1 March 2010
Background:HIV-infected patients receiving antiretroviral therapy often demonstrate excess visceral fat. A growth hormone-releasing factor, tesamorelin, may selectively reduce visceral fat in this… Expand
Carry-over in cross-over trials in bioequivalence: theoretical concerns and empirical evidence
We present theoretical arguments that show that, just as in the AB/BA case, the strategy of pre-testing is biased as a whole and also that the loss in terms of efficiency in adjusting is not negligible. Expand
Additional results for 'Sequential design approaches for bioequivalence studies with crossover designs'.
- Timothy H. Montague, D. Potvin, C. Diliberti, W. Hauck, A. Parr, Donald J. Schuirmann
- Computer Science, Medicine
- Pharmaceutical statistics
In 2008, this group published a paper on approaches for two-stage crossover bioequivalence studies that allowed for the reestimation of the second-stage sample size based on variance estimated from the first-stage results. Expand
Treatment of familial hypercholesterolemia in children and adolescents: effect of lovastatin. Canadian Lovastatin in Children Study Group.
OBJECTIVE Familial hypercholesterolemia (FH), an inherited autosomal dominant disorder of lipoprotein metabolism, is associated with premature atherosclerosis. The recommended pediatric therapy… Expand
Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter,…
- J. Falutz, J. Mamputu, +6 authors S. Grinspoon
- The Journal of clinical endocrinology and…
- 1 September 2010
CONTEXT HIV patients treated with antiretroviral therapy (ART) often develop increased visceral adipose tissue (VAT). OBJECTIVE Our objective was to perform a pooled analysis of two phase-3 studies… Expand
Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation
Objective:Treatment of HIV patients with daily tesamorelin, a growth hormone-releasing factor analogue, for 26 weeks resulted in a significant decrease in visceral adipose tissue (VAT) and… Expand
Predisposing Factors Related to Prosthetic Use by People with a Transtibial and Transfemoral Amputation
A survey was conducted to evaluate prosthetic use and factors predisposing to prosthetic use among 396 adults with unilateral amputations. A response rate of 76% was obtained. Eighty-five percent of… Expand