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Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes
Listeria monocytogenes was used as a model intracellular parasite to study stages in the entry, growth, movement, and spread of bacteria in a macrophage cell line. The first step in infection isExpand
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c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
Bacterial (Interferon)ce Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the cytosol of host immune cells, where they induce a host response that is often dependentExpand
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Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors.
Two site-specific shuttle integration vectors were developed with two different chromosomal bacteriophage integration sites to facilitate strain construction in Listeria monocytogenes. The firstExpand
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Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.
Actin filament assembly at the cell surface of the pathogenic bacterium Listeria monocytogenes requires the bacterial ActA surface protein and the host cell Arp2/3 complex. Purified Arp2/3 complexExpand
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Role of hemolysin for the intracellular growth of Listeria monocytogenes
Listeria monocytogenes insertion mutants defective in hemolysin production were generated using the conjugative transposons Tn916 and Tn1545. All of the nonhemolytic mutants (hly-) lacked a secretedExpand
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SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis
Pathogenic bacteria secrete proteins that promote invasion of host tissues and resistance to immune responses. However, secretion mechanisms that contribute to the enormous morbidity and mortality ofExpand
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The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides
ABSTRACT Type I interferons (IFNs) are central regulators of the innate and adaptive immune responses to viral and bacterial infections. Type I IFNs are induced upon cytosolic detection of microbialExpand
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The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread.
Listeria monocytogenes secretes two distinct phospholipases C, a phosphatidylinositol-specific phospholipase C (PI-PLC) and a broad-range phospholipase C (PC-PLC). In this study, single in-frameExpand
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Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.
The dominant conceptual framework for understanding innate immunity has been that host cells respond to evolutionarily conserved molecular features of pathogens called pathogen-associated molecularExpand
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Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.
Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis isExpand
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