Central nervous system control of food intake
- M. Schwartz, S. Woods, D. Porte, R. Seeley, D. Baskin
- Biology, MedicineNature
- 6 April 2000
A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
Signals that regulate food intake and energy homeostasis.
- S. Woods, R. Seeley, D. Porte, M. Schwartz
- 29 May 1998
This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs.
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
- M. Schwartz, E. Peskind, M. Raskind, E. Boyko, D. Porte
- Biology, MedicineNature Network Boston
- 1 May 1996
It is hypothesized that a saturable mechanism mediates CSF leptin transport, and that reduced efficiency of brain leptin delivery among obese individuals with high plasma leptin levels results in apparent leptin resistance.
Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice
- M. Schwartz, D. Baskin, D. Weigle
- 1 April 1996
In ob/ob mice, systemic administration of leptin inhibits NPY gene overexpression through a specific action in the arcuate nucleus and exerts a hypoglycemic action that is partly independent of its weight-reducing effects.
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure: A Consensus Statement From the American Heart Association and American Diabetes Association
Because people with diabetes are at increased risk for CVD and many have preexisting heart disease, the edema that sometimes accompanies the use of a TZD can be cause for concern, as it may be a harbinger or sign of congestive heart failure (CHF).
Diabetes, Obesity, and the Brain
- M. Schwartz, D. Porte
- Medicine, BiologyScience
- 21 January 2005
This work has shown that adaptive changes occur that promote energy homeostasis and the maintenance of blood glucose levels in the normal range and are implicated in the link between obesity and type 2 diabetes.
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
- S. Woods, E. C. Lotter, L. Mckay, D. Porte
- 29 November 1979
Additional evidence is presented by showing that in baboons the infusion of exogenous insulin into the CSF elicits a reliable and predictable decrease in food intake and body weight.
Insulin in the brain: a hormonal regulator of energy balance.
- M. Schwartz, D. Figlewicz, D. Baskin, S. Woods, D. Porte
- BiologyEndocrine reviews
- 1 August 1992
Recent investigations indicate that “brain insulin” is derived largely from the circulation, and a growing body of evidence suggests that its delivery into the neuropil may be facilitated by a specialized BBB barrier.
Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight
- D. Baskin, D. Lattemann, R. Seeley, S. Woods, D. Porte, M. Schwartz
- BiologyBrain Research
- 27 November 1999
Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.
- W. Ward, D. Bolgiano, B. McKnight, J. Halter, D. Porte
- Medicine, BiologyJournal of Clinical Investigation
- 1 October 1984
It is suggested that patients with NIDDM possess markedly decreased maximal insulin responsiveness to the potentiating effects of glucose, which indicates the presence of a reduced B cell secretory capacity and suggests a marked generalized impairment of B cell function in patients withNIDDM.