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Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
In vertebrates, including humans, individuals harbor gut microbial communities whose species composition and relative proportions of dominant microbial groups are tremendously varied. AlthoughExpand
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Identification of quantitative trait loci affecting reproduction in pigs.
The objective of this research was to identify chromosomal regions harboring QTL affecting reproduction in pigs. A three-generation resource population was developed by crossing low-indexing pigsExpand
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The Collaborative Cross, a community resource for the genetic analysis of complex traits
The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouseExpand
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Bayesian Model Selection for Genome-Wide Epistatic Quantitative Trait Loci Analysis
The problem of identifying complex epistatic quantitative trait loci (QTL) across the entire genome continues to be a formidable challenge for geneticists. The complexity of genome-wide epistaticExpand
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The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population
The Collaborative Cross Consortium reports here on the development of a unique genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant inbred panel derived from eightExpand
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Genetic analysis of complex traits in the emerging Collaborative Cross.
The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resource for mammalian systems genetics. Here we describe an experiment that uses partially inbredExpand
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Candidate gene analysis for loci affecting litter size and ovulation rate in swine.
A candidate gene approach was used to determine whether specific loci explain responses in ovulation rate (OR) and number of fully formed (FF), live (NBA), stillborn, and mummified pigs at birthExpand
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Restriction fragment length polymorphism in amplification products of the bovine PIT1 gene and assignment of PIT1 to bovine chromosome 1.
A polymorphism was identified in the bovine PIT1 gene by digesting polymerase chain reaction (PCR) products with the restriction enzyme HinfI. This polymorphism was segregating in five diverse breedsExpand
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The nature and identification of quantitative trait loci: a community's view
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci thatExpand
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Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains.
Substantial variability exists in collateral density and ischemia-induced collateral growth among species. To begin to probe the underlying mechanisms, which are unknown, we characterized two mouseExpand
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