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International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions
Revised criteria are proposed for pediatric acute disseminated encephalomyelitis, pediatric clinically isolated syndrome, pediatric neuromyELitis optica and pediatric MS to incorporate advances in delineating the clinical and neuroradiologic features of these disorders. Expand
Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study
Risk of multiple sclerosis in children can be stratified by presence of HLA-DRB1*15 alleles, remote Epstein-Barr virus infection, and low serum 25-hydroxyvitamin D concentrations, suggesting established disease. Expand
Lactose malabsorption and intolerance: pathogenesis, diagnosis and treatment
Lactose intolerance has recently been defined as symptoms developing after ingestion of lactose which do not develop after placebo challenge in a person with lactose maldigestion. Expand
Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey
The incidence of children's multiple sclerosis in Germany is more than fourfold higher than that of paediatric ADEM; in addition, it shows a strikingly different age-distribution. Expand
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
A sensitive assay based on self-assembling radiolabeled tetramers that allows discrimination of antibodies against folded or denatured myelin oligodendrocyte glycoprotein (MOG) by selective unfolding of the antigen domain is developed. Expand
Treatment of early onset multiple sclerosis with subcutaneous interferon beta-1a
Treatment with IFNβ-1a was safe and well tolerated in the majority of children and adolescents and laboratory abnormalities included asymptomatic leukopenia and elevated hepatic transaminases. Expand
Achalasia: an overview of diagnosis and treatment.
  • D. Pohl, R. Tutuian
  • Medicine
  • Journal of gastrointestinal and liver diseases…
  • 1 September 2007
Diagnosis of achalasia requires shrewd history taking and dedicated esophageal testing, and treatment can provide long-term sustained clinical improvement. Expand
Clinical spectrum of 4H leukodystrophy caused by POLR3A and POLR3B mutations
Systematic MRI review revealed that the combination of hypomyelination with relative T2 hypointensity of the ventrolateral thalamus, optic radiation, globus pallidus, and dentate nucleus, cerebellar atrophy, and thinning of the corpus callosum suggests the diagnosis of 4H. Expand
High seroprevalence of Epstein–Barr virus in children with multiple sclerosis
We studied seroprevalence and concentrations of Epstein–Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed aExpand
Consensus statement: evaluation of new and existing therapeutics for pediatric multiple sclerosis
The IPMSSG endorses the inclusion of pediatric MS patients in trials evaluating appropriate new and emerging therapies, and concludes that all MS patients, irrespective of age, benefit from advances in MS therapeutics. Expand