Synthesis and antibacterial properties of silver nanoparticles.
- C. Baker, A. Pradhan, L. Pakstis, D. Pochan, S. Shah
- Materials ScienceJournal of Nanoscience and Nanotechnology
- 1 February 2005
The silver nanoparticles synthesized by inert gas condensation and co-condensation techniques were found to exhibit antibacterial effects at low concentrations and the antibacterial properties were related to the total surface area of the nanoparticles.
Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide.
- J. Schneider, D. Pochan, B. Ozbas, K. Rajagopal, L. Pakstis, Juliana K Kretsinger
- Biology, Materials ScienceJournal of the American Chemical Society
- 23 November 2002
Characterization of the gelation process, from the molecular level up through the macroscopic properties of the material, suggests that by linking the intramolecular folding of small designed peptides to their ability to self-assemble, responsive materials can be prepared.
Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells
- Lisa A Haines-Butterick, K. Rajagopal, J. Schneider
- Biology, EngineeringProceedings of the National Academy of Sciences
- 8 May 2007
A peptide-based hydrogelation strategy has been developed that allows homogenous encapsulation and subsequent delivery of C3H10t1/2 mesenchymal stem cells and gel/cell constructs stay fixed at the point of introduction, suggesting that these gels may be useful for the delivery of cells to target biological sites in tissue regeneration efforts.
Poly (l-Lactic Acid)/Layered Silicate Nanocomposite: Fabrication, Characterization, and Properties
The possibility of making rigid polymer layered nanocomposites from biocompatible/biodegradable matrixes was explored. Three types of commercially available organophilic clay were employed to…
Rheological Properties of Peptide-Based Hydrogels for Biomedical and Other Applications
Unusual Crystallization Behavior of Organoclay Reinforced Poly(l-lactic acid) Nanocomposites
The effect of organically modified montmorillonite clay addition on crystallization of a polymer matrix has been studied. Two types of commercially available organoclays with different extent of…
Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles
Diblock copolypeptide amphiphiles containing charged and hydrophobic segments are synthesized and shape-specific supramolecular assembly is integral to the gelation process, and provides a new class of peptide-based hydrogels with potential for applications in biotechnology.
Tuning the pH responsiveness of beta-hairpin peptide folding, self-assembly, and hydrogel material formation.
- K. Rajagopal, M. Lamm, Lisa A Haines-Butterick, D. Pochan, J. Schneider
- Biology, EngineeringBiomacromolecules
- 7 August 2009
A design strategy to control the thermally triggered folding, self-assembly, and subsequent hydrogelation of amphiphilic beta-hairpin peptides in a pH-dependent manner yielded a peptide MAX1(K15E) that is capable of undergoing thermally trigger hydrogels at physiological buffer conditions.
Peptide-based and polypeptide-based hydrogels for drug delivery and tissue engineering.
This chapter highlights recent progress in bio-inspired peptide and polypeptide hydrogels that have potential biomedical and pharmaceutical applications and focuses on synthetic or biosynthetic poly(amino acid) hydrogel based on α-helical coiled-coils, β-sheets, dipeptides, peptide amphiphiles, elastin-like peptides.
Inherent antibacterial activity of a peptide-based beta-hairpin hydrogel.
- Daphne A. Salick, Juliana K Kretsinger, D. Pochan, J. Schneider
- BiologyJournal of the American Chemical Society
A hydrogel scaffold from the self-assembling peptide, MAX1, for tissue regeneration applications whose surface exhibits inherent antibacterial activity is designed, which makes MAX1 gels attractive candidates for use in tissue regeneration, even in nonsterile environments.