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The integrated landscape of driver genomic alterations in glioblastoma
Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a computational platform that integrates the analysis of copy number variations and somatic mutations andExpand
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Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.
Precision medicine is an approach that takes into account the influence of individuals' genes, environment, and lifestyle exposures to tailor interventions. Here, we describe the development of aExpand
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MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is intrinsicallyExpand
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Modeling Patient-Derived Glioblastoma with Cerebral Organoids.
The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a "normal" humanExpand
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Pearls and Oy-sters: Tuberculous meningitis
A 21-year-old man presented to his local emergency department with 5 days of headache, which was dull, occipital, bilateral, nonthrobbing, and progressively worsening. It was associated with mildExpand
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A Case of Late-Onset Leukoencephalopathy, Calcifications, and Cysts Presenting with Intracerebral Hemorrhage Resembling a Neoplasm
In 1996, Labrune et al. [1] described a clinical entity in 3 children with multiple calcifications in deep gray structures, leukoencephalopathy, and parenchymal cysts on neuroimaging. Brain biopsyExpand
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Coronary Artery Calcification: From Mechanism to Molecular Imaging.
Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence of calcification may change portions of the arterial conduit to a noncompliant structure. CalcificationsExpand
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Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions ofExpand
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The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations
This paper describes the Precision Medicine Knowledge Base (PMKB; https://pmkb.weill.edu), an interactive online application for collaborative editing, maintenance, and sharing of structured clinical-grade cancer mutation interpretations. Expand
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Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models.
Purpose Patients with cancer who graciously consent for autopsy represent an invaluable resource for the study of cancer biology. To advance the study of tumor evolution, metastases, and resistanceExpand
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