• Publications
  • Influence
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
  • J. Hagan, R. Leslie, +18 authors N. Upton
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 14 September 1999
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely inExpand
In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties
1 SB 206553 (5‐methyl‐1‐(3‐pyridylcarbamoyl)‐1,2,3,5‐tetrahydropyrrolo[2,3‐f]indole) displays a high affinity (pK1 7.9) for the cloned human 5‐HT2C receptor expressed in HEK 293 cells and the 5‐HT2BExpand
Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist
The novel 5‐HT7 receptor antagonist, SB‐269970‐A, potently displaced [3H]‐5‐CT from human 5‐HT7(a) (pKi 8.9±0.1) and 5‐HT7 receptors in guinea‐pig cortex (pKi 8.3±0.2). 5‐CT stimulated adenylylExpand
The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats
Orexin‐A is a novel neuropeptide initially isolated from hypothalamic extracts but now known to be present in fibres distributed throughout the rat CNS including many regions associated withExpand
Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat
The neuropeptide orexin-A modulates the sleep-wake cycle such that central administration to rats increases arousal, reduces slow-wave-sleep (SWS) and paradoxical sleep (PS) and delays PS onset. TheExpand
Effect of SB-243213, a selective 5-HT2C receptor antagonist, on the rat sleep profile A comparison to paroxetine
5-HT(2) receptor antagonists promote slow wave sleep (SWS) in humans and rats, conversely 5-HT(2) agonists inhibit SWS in rats. These alterations are thought to be predominantly mediated via theExpand
SB‐334867, a selective orexin‐1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin‐A in rats
Intracerebroventricular (i.c.v.) administration of the novel hypothalamic neuropeptide orexin‐A stimulates food intake in rats, and delays the onset of behavioural satiety (i.e. the naturalExpand
Marmoset Conspecific Confrontation: An Ethologically-Based Model of Anxiety
  • J. Cilia, D. Piper
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 1 September 1997
A method of measuring confrontation-induced behavioural changes in common marmosets (Callithrix jacchus) together with automated monitoring of locomotor activity has been developed as a possibleExpand
Clozapine enhances breakpoint in common marmosets responding on a progressive ratio schedule
Abstract Rationale: Motivational effects of psychotropic drugs may contribute to their therapeutic profile and progressive ratio (PR) schedules provide a method of measuring these effects in animals.Expand
Effects of agents which enhance GABA-mediated neurotransmission on licking conflict in rats and exploration in mice.
On the holeboard, exploration (dipping) and locomotion of mice were enhanced by non-sedative doses of anxiolytics; clobazam, diazepam, nitrazepam and flunitrazepam. After chronic dosing the sedativeExpand