D. Piper | Semantic Scholar

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

J. Hagan, R. Leslie, N. Upton
Biology, Psychology
Proceedings of the National Academy of Sciences…
14 September 1999

It is shown that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexIn A increases cell firing of intrinsic noradrenergic neurones and modulates neuroendocrine function.

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Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist

J. Hagan, G. W. Price, D. Thomas
Biology, Medicine
British journal of pharmacology
1 June 2000

A role for 5‐HT7 receptor stimulation in 5‐CT induced hypothermia in guinea‐pigs is suggested, and time spent in Paradoxical Sleep (PS) during the first 3 h of EEG recording in conscious rats is significantly reduced.

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In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties

G. Kennett, M. Wood, T. Blackburn
Biology, Psychology
British journal of pharmacology
1 February 1996

The results suggest that SB 206553 is a potent mixed 5‐HT2C/5-HT2B receptor antagonist with selectivity over the 5‐ HT2A and all other sites studied and possesses anxiolytic‐like properties.

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The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

D. Piper, N. Upton, Martin I. Smith, A. Hunter
Biology, Psychology
The European journal of neuroscience
1 February 2000

It is concluded that orexin‐A may play an important physiological role in regulating the sleep–wake state, a hypothesis considerably strengthened by the recently reported narcoleptic phenotype of prepro‐orexin (the precursor for orexIn‐A) knockout mice.

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Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat

M. I. Smith, D. Piper, M. Duxon, N. Upton
Biology, Psychology
Neuroscience Letters
8 May 2003

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Effect of SB-243213, a selective 5-HT2C receptor antagonist, on the rat sleep profile A comparison to paroxetine

M. I. Smith, D. Piper, M. Duxon, N. Upton
Biology, Psychology
Pharmacology Biochemistry and Behavior
1 April 2002

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Dose–response effects of orexin-A on food intake and the behavioural satiety sequence in rats

R. Rodgers, J. Halford, J. Blundell
Biology, Psychology
Regulatory Peptides
22 December 2000

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SB‐334867, a selective orexin‐1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin‐A in rats

R. Rodgers, J. Halford, J. Blundell
Biology, Psychology
The European journal of neuroscience
1 April 2001

The view that orexin‐A is involved in the regulation of feeding patterns and that this influence is mediated through the orexIn‐1 receptor is strongly supported.

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Marmoset Conspecific Confrontation: An Ethologically-Based Model of Anxiety

J. Cilia, D. Piper
Psychology, Biology
Pharmacology Biochemistry and Behavior
1 September 1997

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Clozapine enhances breakpoint in common marmosets responding on a progressive ratio schedule

J. Cilia, D. Piper, N. Upton, J. Hagan
Psychology, Medicine
Psychopharmacology
14 March 2001

It is demonstrated that, unlike other antipsychotic drugs, clozapine over a wide dose range increased the motivational state of marmosets to respond for banana milkshake, and the PR procedure may provide a method for detecting novel antipsychotics with a clozAPine-like profile.

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