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Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes.
The data help to unravel the complexities of the tumor-infiltrating myeloid cell compartment and provide a rationale for targeting specialized TAM subsets, thereby optimally "re-educating" the TAM compartment.
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
It is concluded that FFAs can cause death of normal rat islet cells through an NO-independent mechanism and the ability of normal beta-cells to form and accumulate cytoplasmic triglycerides might serve as a cytoprotective mechanism against FFA-induced apoptosis by preventing a cellular rise in toxic free fatty acyl moieties.
Metabolic Fate of Glucose in Purified Islet Cells
The results support the view that anaplerosis is an essential pathway implicated in β cell activation by glucose, and rat β cells metabolize glucose essentially via aerobic glycolysis, whereas gly colysis in α cells is largely anaerobic.
Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.
It is proposed that similar metabolic signaling pathways influence the function of pancreatic alpha-cells, hypothalamic neurons, and gastrointestinal endocrine and neural cells, with important roles for glucokinase and mitochondrial oxidative fluxes in the regulation of ATP-sensitive K+ channels.
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1
- D. Delmeire, D. Flamez, S. Hinke, J. Cali, D. Pipeleers, F. Schuit
- Biology, ChemistryDiabetologia
- 17 September 2003
This study identifies type VIII AC in insulin-secreting cells as one of the potential molecular targets for synergism between GLP-1 receptor mediated and glucose-mediated signalling.
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
- B. Keymeulen, E. Vandemeulebroucke, L. Chatenoud
- Medicine, BiologyThe New England journal of medicine
- 23 June 2005
Short-term treatment with CD3 antibody preserves residual beta-cell function for at least 18 months in patients with recent-onset type 1 diabetes, as suggested by the results of a phase 1 study.
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata and underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.
A new in vitro model for the study of pancreatic A and B cells.
- D. Pipeleers, P. in’t Veld, M. Van De Winkel, E. Maes, F. Schuit, W. Gepts
- Biology, MedicineEndocrinology
- 1 September 1985
A method is developed for the preparation of single, pure, and viable rat pancreatic A and B cells in numbers sufficient for in vitro analysis and is expected to contribute to the understanding of the regulation of glucagon and insulin release.
Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program.
- A. Hoorens, M. Van de Casteele, G. Klöppel, D. Pipeleers
- BiologyThe Journal of clinical investigation
- 1 October 1996
Data indicate that glucose promotes survival of beta cells by activating synthesis of proteins which suppress apoptosis, which explains earlier observed effects of glucose on survival of cultured beta cells.