Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.
- A. Breier, T. Su, D. Pickar
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 18 March 1997
In the clinical study, patients with schizophrenia compared with healthy volunteers had significantly greater amphetamine-related reductions in [11C]raclopride specific binding, providing direct evidence for the hypothesis of elevated Amphetamine-induced synaptic dopamine concentrations in schizophrenia.
NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers
- A. Malhotra, D. Pinals, A. Breier
- Psychology, BiologyNeuropsychopharmacology
- 1 May 1996
Cognitive substrates of thought disorder, I: the semantic system.
- T. Goldberg, M. Aloia, M. Gourovitch, D. Missar, D. Pickar, D. Weinberger
- Psychology, MedicineAmerican Journal of Psychiatry
- 1 December 1998
The results suggest that clinically rated thought disorder is associated with and may result from semantic processing abnormalities and patients with more severe thought disorder may have difficulty accessing semantic items because of disorganization of the semantic systems and, to a more limited degree, may also lack a semantic or conceptual knowledge base.
Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics
- A. Malhotra, D. Pinals, A. Breier
- Psychology, MedicineNeuropsychopharmacology
- 1 September 1997
Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers.
- A. Breier, A. Malhotra, D. Pinals, N. Weisenfeld, D. Pickar
- Medicine, PsychologyAmerican Journal of Psychiatry
- 1997
Data suggest that the prefrontal cortex may be involved in mediating NMDA receptor-induced psychosis, and a change in one psychotic symptom, conceptual disorganization, was significantly related to prefrontal activation.
Effects of Ketamine on Thought Disorder, Working Memory, and Semantic Memory in Healthy Volunteers
- C. Adler, T. Goldberg, A. Malhotra, D. Pickar, A. Breier
- Psychology, MedicineBiological Psychiatry
- 1 June 1998
Neuropsychiatric effects of anabolic steroids in male normal volunteers.
- T. Su, M. Pagliaro, P. Schmidt, D. Pickar, O. Wolkowitz, D. Rubinow
- Medicine, PsychologyJAMA
- 2 June 1993
This is the first placebo-controlled prospective study demonstrating the adverse and activating mood and behavioral effects of anabolic steroids.
Quantification of Amphetamine-Induced Changes in [11C]Raclopride Binding with Continuous Infusion
- R. Carson, A. Breier, W. Eckelman
- BiologyJournal of Cerebral Blood Flow and Metabolism
- 1 April 1997
This study demonstrates that stimulus-induced changes in specific binding can be measured with a single [11C]raclopride study using the B/I method.
Cognitive effects of corticosteroids.
- O. Wolkowitz, V. Reus, D. Pickar
- Psychology, MedicineAmerican Journal of Psychiatry
- 1990
Findings raise the possibility of specific corticosteroid-related cognitive impairments in depressed patients,healthy volunteers given a single 1-mg dose of dexamethasone, and healthy volunteers given 80 mg/day of prednisone for 5 days.
The Effect of Clozapine on Cognition and Psychiatric Symptoms in Patients with Schizophrenia
- T. Goldberg, Richard Greenberg, D. Weinberger
- Psychology, MedicineBritish Journal of Psychiatry
- 1 January 1993
Despite improvements in psychiatric symptoms, attention, memory, and higher-level problem-solving were essentially unchanged, suggesting that certain cognitive deficits are relatively independent of psychotic symptoms in schizophrenia, and are probably central and enduring features of the disorder.
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