• Publications
  • Influence
Precise estimates of mutation rate and spectrum in yeast
This work sequencing the genomes of 145 diploid mutation accumulation (MA) lines of the budding yeast Saccharomyces cerevisiae identified nearly 1,000 mutations, a larger number than in any prior eukaryotic MA experiment as far as the authors are aware, and for the first time, in MA data, rates of context-dependent single-nucleotide mutations are estimated.
Recent Selective Sweeps in North American Drosophila melanogaster Show Signatures of Soft Sweeps
A statistical test based on a measure of haplotype homozygosity (H12) that is capable of detecting both hard and soft sweeps with similar power is developed, and it is found that the H12 and H2/H1 values for all top 50 peaks are much more easily generated by soft rather than hard sweeps.
Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer
These studies illustrate how major expression and morphological changes can arise from single mutational leaps in natural populations, producing new adaptive alleles via recurrent regulatory alterations in a key developmental control gene.
Pervasive Natural Selection in the Drosophila Genome?
Analyses of genetic variation within and between species reveal that much of the Drosophila genome is under purifying selection, and thus of functional importance, and that a large fraction of coding and noncoding differences between species are adaptive.
Genomic Evidence of Rapid and Stable Adaptive Oscillations over Seasonal Time Scales in Drosophila
This work hypothesized that environmental fluctuations among seasons in a North American orchard would impose temporally variable selection on Drosophila melanogaster that would drive repeatable adaptive oscillations at balanced polymorphisms, and identified hundreds of polymorphisms whose frequency oscillates among seasons and argued that these loci are subject to strong, temporal variable selection.
High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography
It is suggested that the current increases in human population, urbanization, and global travel, combined with the population genetic characteristics of M. tuberculosis described here, could contribute to the emergence and spread of drug-resistant tuberculosis.
The large genome constraint hypothesis: evolution, ecology and phenotype.
It is found that species with large genomes have reduced maximum photosynthetic rates - suggesting a large genome constraint on plant performance, and whether these phenotypic correlations may help explain why species are trimmed from the evolutionary tree and have restricted ecological distributions.
Evidence That Mutation Is Universally Biased towards AT in Bacteria
It is demonstrated that clonal pathogens that evolve under severely relaxed selection are uniquely suitable for studying mutational biases in bacteria and that variation in nucleotide content cannot stem entirely from variation inmutational biases and that natural selection and/or a natural selection-like process such as biased gene conversion strongly affect nucleotidecontent.
Mutational equilibrium model of genome size evolution.
  • D. Petrov
  • Biology
    Theoretical population biology
  • 1 June 2002
A mutational equilibrium model of genome size evolution is described, which suggests that the long-term variation is genome size in animals is brought about to a significant extent by changes in the intrinsic rates of DNA loss through small deletions.