• Publications
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Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data
TLDR
We present a modular approach for analyzing calcium imaging recordings of large neuronal ensembles. Expand
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RuBi-Glutamate: Two-Photon and Visible-Light Photoactivation of Neurons and Dendritic spines
We describe neurobiological applications of RuBi-Glutamate, a novel caged-glutamate compound based on ruthenium photochemistry. RuBi-Glutamate can be excited with visible wavelengths and releasesExpand
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Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation
Optogenetics with microbial opsin genes has enabled high-speed control of genetically specified cell populations in intact tissue. However, it remains a challenge to independently control subsets ofExpand
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Two-photon optogenetics of dendritic spines and neural circuits in 3D
We demonstrate a two-photon optogenetic method that generates action potentials in neurons with single-cell precision, using the red-shifted opsin C1V1T. We applied the method to optically mapExpand
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Imaging Voltage in Neurons
In the last decades, imaging membrane potential has become a fruitful approach to study neural circuits, especially in invertebrate preparations with large, resilient neurons. At the same time,Expand
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Imprinting and recalling cortical ensembles
Building new networks in the brain Donald Hebb's hypothesis that coactivation of neurons leads to the formation of ensembles of neurons has inspired neuroscientists for decades. The experimentalExpand
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SLM Microscopy: Scanless Two-Photon Imaging and Photostimulation with Spatial Light Modulators
Laser microscopy has generally poor temporal resolution, caused by the serial scanning of each pixel. This is a significant problem for imaging or optically manipulating neural circuits, sinceExpand
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Simultaneous Multi-plane Imaging of Neural Circuits
Recording the activity of large populations of neurons is an important step toward understanding the emergent function of neural circuits. Here we present a simple holographic method toExpand
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Simultaneous imaging of neural activity in three dimensions
TLDR
We introduce a scanless optical method to image neuronal activity in three dimensions simultaneously. Expand
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Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions
The simultaneous imaging and manipulating of neural activity could enable the functional dissection of neural circuits. Here we have combined two-photon optogenetics with simultaneous volumetricExpand
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