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Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.
Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.
Synthesis and biological activity of imidazopyridine anticoccidial agents: part I.
Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.
- D. Perrey, N. German, +4 authors Yanan Zhang
- Chemistry, MedicineJournal of medicinal chemistry
- 26 August 2013
A series of substituted tetrahydroisoquinolines were designed and synthesized and determined their potency in OX1 and OX2 calcium mobilization assays, revealing limited steric tolerance and a preference for electron deficiency at the 7-position in rats.
Synthesis of peptide analogues containing phosphonamidate methyl ester functionality: HIV-1 proteinase inhibitors possessing unique cell uptake properties.
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II.
Toward the Development of Bivalent Ligand Probes of Cannabinoid CB1 and Orexin OX1 Receptor Heterodimers.
- D. Perrey, B. Gilmour, B. Thomas, Yanan Zhang
- Biology, MedicineACS medicinal chemistry letters
- 27 March 2014
Bivalent ligands targeting CB1-OX1 receptor dimers could be potentially useful as a tool for further exploring the roles of such heterodimers in vitro and in vivo.
Therapeutics development for addiction: Orexin-1 receptor antagonists
Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling
- K. A. Levy, Z. Brodnik, J. Shaw, D. Perrey, Y. Zhang, R. España
- 30 June 2017
Doses of RTIOX-276 that attenuate the motivation for cocaine reduce spontaneous dopamine transient amplitude and cue-evoked dopamine release, and elucidate a second process through which HCRTr1 blockade attenuates the effects of cocaine by reducing cocaine sensitivity at dopamine terminals.