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Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.
Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.
TLDR
A series of substituted tetrahydroisoquinolines were designed and synthesized and determined their potency in OX1 and OX2 calcium mobilization assays, revealing limited steric tolerance and a preference for electron deficiency at the 7-position in rats.
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II.
Toward the Development of Bivalent Ligand Probes of Cannabinoid CB1 and Orexin OX1 Receptor Heterodimers.
TLDR
Bivalent ligands targeting CB1-OX1 receptor dimers could be potentially useful as a tool for further exploring the roles of such heterodimers in vitro and in vivo.
Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling
TLDR
Doses of RTIOX-276 that attenuate the motivation for cocaine reduce spontaneous dopamine transient amplitude and cue-evoked dopamine release, and elucidate a second process through which HCRTr1 blockade attenuates the effects of cocaine by reducing cocaine sensitivity at dopamine terminals.
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