A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
It is shown that histone H3 lysine 9 (H3K9) methylation is the primary epigenetic determinant for the intermediate pre-iPSC state, and its removal leads to fully reprogrammed iPSCs.
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
A structure-assisted optimization program has yielded compounds with fast in vitro inactivation of multiple CoV Mpros, potent antiviral activity, and extremely low cellular toxicity in cell-based assays.
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.
Treating COVID-19 with Chloroquine
Generation of Induced Pluripotent Stem Cell Lines from Tibetan Miniature Pig*
The successful generation of pluripotent stem cells from fibroblasts isolated from the Tibetan miniature pig using a modified iPS protocol more closely resemble human ESC than cells from other species is reported.
Regulation of the Pluripotency Marker Rex-1 by Nanog and Sox2*
- W. Shi, Hui Wang, G. Pan, Yijie Geng, Yunqian Guo, D. Pei
- BiologyJournal of Biological Chemistry
- 18 August 2006
It is demonstrated that the C terminus of Nanog is responsible for transactivating the Rex-1 promoter, a function that can be substituted for by a viral transactivator Vp16 efficiently in NIH3T3 cells but less so in P19 cells.
Genomic instability in laminopathy-based premature aging
The results indicate that unprocessed prelamin A and truncated lamin A act dominant negatively to perturb DNA damage response and repair, resulting in genomic instability which might contribute to laminopathy-based premature aging.
Membrane type-matrix metalloproteinases (MT-MMP).
Vitamin C modulates TET1 function during somatic cell reprogramming
It is reported that TET1 either positively or negatively regulates somatic cell reprogramming depending on the absence or presence of vitamin C, and it is suggested that vitamin C has a vital role in determining the biological outcome of Tet1 function at the cellular level.