A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.
- Ronghui Li, Jialiang Liang, D. Pei
- BiologyCell Stem Cell
- 2 July 2010
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
- Jiekai Chen, He Liu, D. Pei
- Biology, ChemistryNature Genetics
- 2013
It is shown that histone H3 lysine 9 (H3K9) methylation is the primary epigenetic determinant for the intermediate pre-iPSC state, and its removal leads to fully reprogrammed iPSCs.
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
- Haitao Yang, W. Xie, Z. Rao
- BiologyPLoS Biology
- 6 September 2005
A structure-assisted optimization program has yielded compounds with fast in vitro inactivation of multiple CoV Mpros, potent antiviral activity, and extremely low cellular toxicity in cell-based assays.
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.
- M. Esteban, Tao Wang, D. Pei
- BiologyCell Stem Cell
- 8 January 2010
Treating COVID-19 with Chloroquine
- Mingxing Huang, T. Tang, H. Shan
- MedicineJournal of Molecular Cell Biology
- 1 April 2020
Generation of Induced Pluripotent Stem Cell Lines from Tibetan Miniature Pig*
- M. Esteban, Jianyong Xu, D. Pei
- BiologyJournal of Biological Chemistry
- 17 April 2009
The successful generation of pluripotent stem cells from fibroblasts isolated from the Tibetan miniature pig using a modified iPS protocol more closely resemble human ESC than cells from other species is reported.
Regulation of the Pluripotency Marker Rex-1 by Nanog and Sox2*
- W. Shi, Hui Wang, G. Pan, Yijie Geng, Yunqian Guo, D. Pei
- BiologyJournal of Biological Chemistry
- 18 August 2006
It is demonstrated that the C terminus of Nanog is responsible for transactivating the Rex-1 promoter, a function that can be substituted for by a viral transactivator Vp16 efficiently in NIH3T3 cells but less so in P19 cells.
Genomic instability in laminopathy-based premature aging
- Baohua Liu, Jianming Wang, Zhongjun Zhou
- BiologyNature Network Boston
- 26 June 2005
The results indicate that unprocessed prelamin A and truncated lamin A act dominant negatively to perturb DNA damage response and repair, resulting in genomic instability which might contribute to laminopathy-based premature aging.
Membrane type-matrix metalloproteinases (MT-MMP).
- S. Zucker, D. Pei, Jian Cao, C. López-OtÃn
- BiologyCurrent Topics in Developmental Biology
- 2003
Vitamin C modulates TET1 function during somatic cell reprogramming
- Jiekai Chen, Lin Guo, D. Pei
- BiologyNature Genetics
- 1 December 2013
It is reported that TET1 either positively or negatively regulates somatic cell reprogramming depending on the absence or presence of vitamin C, and it is suggested that vitamin C has a vital role in determining the biological outcome of Tet1 function at the cellular level.
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