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Sepsis in European intensive care units: Results of the SOAP study*
This large pan-European study documents the high frequency of sepsis in critically ill patients and shows a close relationship between the proportion of patients with sepsi and the intensive care unit mortality in the various countries. Expand
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
Biomarker-guided immunotherapy that is administered to patients at the proper immune phase of sepsis is potentially a major advance in the treatment of septicaemia and in the field of infectious disease. Expand
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.
It is hypothesised that immunoadjuvant therapy represents the next major advance in sepsis, and explains why many previous sepsi trials which were directed at blocking inflammatory mediators or pathogen recognition signalling pathways failed. Expand
Hydrocortisone therapy for patients with septic shock.
Hydrocortisone did not improve survival or reversal of shock in patients with septic shock, either overall or in patients who did not have a response to corticotropin, although hydroc Cortisone hastened reversal ofshock in patients in whom shock was reversed. Expand
Drotrecogin alfa (activated) in adults with septic shock.
DrotAA did not significantly reduce mortality at 28 or 90 days, as compared with placebo, in patients with septic shock, and rates of death at 28 and 90 days were not significantly different in other predefined subgroups, including patients at increased risk for death. Expand
A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, Microcirculatory Dysfunction, Bioenergetics, and the Tubular Cell Adaptation to Injury
It is proposed that the interplay between inflammation and oxidative stress, microvascular dysfunction, and the adaptive response of the tubular epithelial cell to the septic insult is mostly adaptive in origin, that it is driven by mitochondria, and that it ultimately results in and explains the clinical phenotype of sepsis-induced AKI. Expand
A positive fluid balance is associated with a worse outcome in patients with acute renal failure
In this large European multicenter study, a positive fluid balance was an important factor associated with increased 60-day mortality, and among patients treated with RRT, length of stay and mortality were lower when RRT was started early in the course of the ICU stay. Expand
Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*
It is suggested that dopamine administration may be associated with increased mortality rates in shock, and there is a need for a prospective study comparing dopamine with other catecholamines in the management of circulatory shock. Expand
Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study
IntroductionThe role of systemic hemodynamics in the pathogenesis of septic acute kidney injury (AKI) has received little attention. The purpose of this study was to investigate the associationExpand
Renal replacement therapy in acute kidney injury: controversy and consensus
A review of the available RRT modalities, covering technical and clinical aspects, discusses several controversial issues, provides some practical recommendations, and where possible suggest a research agenda for the future. Expand