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Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
Findings support the association of rare SLITRK1 sequence variants with TS by identifying a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189.
Ritual, habit, and perfectionism: the prevalence and development of compulsive-like behavior in normal young children.
A parent-report questionnaire, the Childhood Routines Inventory (CRI), was developed to assess compulsive-like behavior in young children, and was administered to 1,492 parents with children between the ages of 8 and 72 months.
Reconstructing Native American Population History
It is shown that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America.
Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective
- D. Pauls, A. Abramovitch, S. Rauch, D. Geller
- Psychology, BiologyNature Reviews Neuroscience
- 1 June 2014
Genetic studies indicate that genes affecting the serotonergic, dopaminergic and glutamatergic systems, and the interaction between them, play a crucial part in the functioning of this circuit.
Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome.
It is confirmed that psychiatric comorbidities are common among individuals with TS, demonstrates that most comor bidities begin early in life, and indicates that certain comorbiities may be mediated by the presence of comorbrid OCD or ADHD.
Symptoms of obsessive-compulsive disorder.
The four symptom dimensions identified in this study are largely congruent with those identified in earlier reports, and may be of value in future genetic, neurobiological, and treatment response studies.
Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15.
Six extended dyslexic families with at least four affected individuals were genotyped with markers in three chromosomal regions, appearing to link two very distinct reading-related phenotypes, reflecting different levels in the hierarchy of reading- related skills, each contributing to different processes.
Disruption of neurexin 1 associated with autism spectrum disorder.
Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study
- M. Mattila, T. Hurtig, I. Moilanen
- Psychology, MedicineJournal of autism and developmental disorders
- 23 February 2010
The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based…
A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q.
This genome scan indicated several regions of interest, two of which showed suggestive evidence for linkage, and the most promising chromosome region was located at 15q, with an MLS of 3.54 under the broad phenotype definition.