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Diffuse-interface theory for structure formation and release behavior in controlled drug release systems.
A diffuse-interface theory for microstructure evolution that is based on interactions between drug, polymer and solvent species, all of which may be present in either crystalline or amorphous states is developed and observed that changes in process time alone can induce differences in bulk release of almost a factor of two and typical non-uniformities of +/-30% during the initial periods of release. Expand
Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
This work synthesized ferric ion–cross-linked networks of HA based on an adhesion barrier, varied the degree of cross-linking, and performed wetting goniometry, viscometry, and dynamic mechanical analysis, finding that wetting and lubrication are compromised. Expand
pH effect on the synthesis, shear properties, and homogeneity of iron-crosslinked hyaluronic acid-based gel/adhesion barrier.
Dynamic mechanical analyses provide evidence that the reaction of HA with Fe(III) ions leads to the formation of "weak" gels, indicating the need for a tight manufacturing control during medical device fabrication. Expand
Antimicrobial and Anti-Biofilm Medical Devices: Public Health and Regulatory Science Challenges
The public health challenge of medical device healthcare associated infections and the regulatory science challenges involved with antimicrobial and anti-biofilm medical device technologies, including coatings and other modifications are introduced. Expand
Impact of artificial plaque composition on drug transport.
An improved tissue mimic or artificial plaque is developed to probe the effect of varying concentrations of plaque constituents on drug transport in vitro and suggests that variations in the chemical characteristics of atherosclerotic plaque can significantly alter the release rate and distribution of drug following DES implantation. Expand
Modeling microstructure development and release kinetics in controlled drug release coatings.
The results suggest that improved comprehension and quantification of the physico-chemical properties in controlled release systems will enable the microstructure to be tailored to achieve desired responses that are insensitive to manufacturing variations. Expand
Predicting gas chromatographic separation and stationary-phase selectivity using computer modeling.
A computer modeling technique has been developed which allows for the prediction of chromatographic separation and stationary-phase selectivity. This technique enables development ofExpand
Characterization of drug-eluting stent (DES) materials with cluster secondary ion mass spectrometry (SIMS)
Secondary ion mass spectrometry (SIMS) employing an SF 5 + polyatomic primary ion source was utilized to analyze several materials commonly used in drug-eluting stents (DES). Poly(ethylene-co-vinylExpand
Modeling solvent evaporation during the manufacture of controlled drug-release coatings and the impact on release kinetics.
Calculations demonstrate that solvent evaporation rate can be as critical to device performance as the amount of drug within the coating, and the predicted structures and release kinetics are found to be consistent with experimental observations. Expand