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Acidophilic Microbes: Biology and Applications
TLDR
The biology of acidophiles, acidstable enzymes and their potential applications, utility of Acidophiles in bioconversion and bioremediation, and in microbial fuel cells to generate electricity are reviewed.
A chimeric α-amylase engineered from Bacillus acidicola and Geobacillus thermoleovorans with improved thermostability and catalytic efficiency
TLDR
Ba-Gt-amy is a suitable biocatalyst for raw starch saccharification at sub-gelatinization temperatures because of its acid stability, thermostability and Ca2+ independence, and better than the other known bacterial acidic α-amylases.
Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy
TLDR
It is suggested that chemokine and immunosuppressive molecule expression profiles can be used to accurately predict clinical responses thus differentiating among patients who would and would not benefit from PD-1 or PD-L1 immunotherapies.
Expression and Humoral Response of A-Kinase Anchor Protein 4 in Cervical Cancer
TLDR
The data indicate the putative role of AKAP4 in early tumorigenesis and may be implicated as a biomarker and immunotherapeutic target for cervical cancer.
Production of Chimeric Acidic α-Amylase by the Recombinant Pichia pastoris and Its Applications
TLDR
The strategy for generating multi-copy clones is being reported for the first time, which could be useful in enhancing the production of other recombinant proteins.
Heat shock protein 70–2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth
TLDR
Investigation of the association of heat shock protein 70–2 with various malignant properties of colorectal cancer cells and clinic-pathological features of CRC in clinical specimens indicates that HSP70-2 may be a potential therapeutic target for CRC treatment.
A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer
TLDR
A-kinase anchor protein 4 appears to be a novel CRC-associated antigen with a potential for developing as a new clinical therapeutic target.
Sperm Associated Antigen 9 Plays an Important Role in Bladder Transitional Cell Carcinoma
TLDR
The data in clinical specimens indicated that SPAG9 is potential biomarker and therapeutic target for bladder TCC, and gene silencing resulted in reduction in cellular growth, and migration and invasion ability of cancer cells in vitro.
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