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Dependence of the Yield of DNA Double-Strand Breaks in Chinese Hamster V79-4 Cells on the Photon Energy of Ultrasoft X Rays
From the size distribution of small DNA fragments down to 0.48 kbp, it is concluded that DSBs are induced randomly by CK and AlK ultrasoft X rays, which are more efficient per unit dose than γ radiation at inducing DNA D SBs.
A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas
It is established that the differentially methylated region at exon 1A contains an imprinting control element that specifically regulates Gnas and comprises a characterized ICR for a gene that is only weakly imprinted in a minority of tissues.
Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation.
The data confirm that alpha-particles induce chromosomal instability but instability is demonstrated in the progeny of nonirradiated stem cells and must be due to unexpected interactions between irradiated and nonIRradiated cells.
The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice.
The quantitative aspects of induction of myeloid leukaemia by ionizing radiation are unlike the induction of genetic mutation or cell inactivation and suggest that interaction of two adjoining cells is an essential element in radiation leukaemogenesis.
In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations
- G. Watson, D. Pocock, D. Papworth, S. Lorimore, E. Wright
- Medicine, BiologyInternational journal of radiation biology
- 1 January 2001
Chromosomal instability induced in vitro can be transmitted in vivo by transplantation of haemopoietic stem cells exposed to high- or low-LET radiations and comparable instability can be induced and shown to persist for the remaining lifetime after whole-body irradiation.
Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero.
It is shown here that imprinting effects are detectable in utero as mice with maternal duplication/paternal deficiency and the reciprocal for this region exhibit phenotypic anomalies at birth and die neonatally.
Investigation of lung tumour induction in BALB/cJ mice following paternal X-irradiation.
- B. Cattanach, G. Patrick, E. Whitehill
- Biology, MedicineInternational journal of radiation biology
The finding that lung tumour incidence in BALB/cJ mice is not affected by paternal germ cell irradiation does not accord with Nomura's reports using other strains of mice, and weakens biological support for a causal association between the raised incidence of childhood leukaemia and non-Hodgkin lymphoma near Sellafield and the father's recorded radiation exposure during employment by the nuclear industry.
The relationship of radiation-induced dicentric yield to chromosome arm number.
Chromosome 2 hypersensitivity and clonal development in murine radiation acute myeloid leukaemia.
It is established that chromosomal aberrations detected in bone marrow cells by chromosome painting are induced in all mice at an approximately 2-fold greater frequency in chr 2 by comparison with chrs 1 and 3 at 24 and 48 h following in vivo whole-body X-irradiation.
X-ray-induced simple, pseudosimple and complex exchanges involving two distinctly painted chromosomes.
The frequency of non-reciprocal rejoining events within complex exchanges is consistent with an interaction model based on the free exchange of multiple break-ends, and the simple and complex exchanges have distinct dose-response curves, in agreement with previous data for single-painted exchanges corrected for pseudosimples.