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Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
TLDR
Sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health, and patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions.
Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia.
TLDR
There is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition.
Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity.
TLDR
It is suggested that TNF alpha and IL-6 might play a significant role in mediating sleepiness and fatigue in disorders of EDS in humans.
The Pathophysiologic Roles of Interleukin-6 in Human Disease
TLDR
What makes interleukin-6 particularly interesting to physicians is its marked pleiotropy and its involvement not only in inflammation but in the regulation of endocrine and metabolic functions.
Chronic Fatigue Syndrome – A clinically empirical approach to its definition and study
TLDR
The empirical definition of chronic fatigue syndrome includes all aspects of CFS specified in the 1994 case definition and identifies persons with CFS in a precise manner that can be readily reproduced by both investigators and clinicians.
Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors.
TLDR
It is reported that histamine dose-dependently inhibited the secretion of human IL-12 and increased the production of IL-10 in LPS-stimulated whole blood cultures and may represent a novel mechanism by which excessive secretion of histamine potentiates Th2-mediated allergic reactions and contributes to the development of certain infections and tumors normally eliminated by Th1-dependent immune mechanisms.
Circadian interleukin-6 secretion and quantity and depth of sleep.
TLDR
It is suggested that a good night's sleep isassociated with decreased daytime secretion of IL-6 and a good sense of well-being and that good sleep is associated with decreased exposure of tissues to the proinflammatory and potentially detrimental actions of IL -6.
Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications.
TLDR
It is suggested that the central nervous system may regulate IL-12 and IL-10 secretion and, hence, TH1/TH2 balance via the peripheral end-effectors of the stress system, which may cause a selective suppression of TH1 functions and a shift toward a TH2 cytokine pattern rather than generalized TH suppression.
Paradoxical Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease
TLDR
The usefulness of the Liddle test is compared in diagnosing primary pigmented nodular adrenocortical disease and in differentiating this disease from other primary adrenOCortical disorders.
Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study.
TLDR
Evidence is provided of increased levels of multiple types of childhood trauma in a population-based sample of clinically confirmed CFS cases compared with nonfatigued controls and results suggest that childhood trauma is an important risk factor for CFS.
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