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Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles
A colorimetric assay based on gold nanoparticles (AuNPs), when capped with suitably designed thiol-modified antisense oligonucleotides (ASOs) specific for N-gene (nucleocapsid phosphoprotein) of SARS-CoV-2, could be used for diagnosing positive COVID-19 cases within 10 min from the isolated RNA samples.
Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip
The development of a rapid (less than 5 min), low-cost, easy-to-implement, and quantitative paper-based electrochemical sensor chip to enable the digital detection of SARS-CoV-2 genetic material is reported.
Revisiting an old friend: manganese-based MRI contrast agents.
- D. Pan, S. Caruthers, A. Senpan, A. Schmieder, S. Wickline, G. Lanza
- MedicineWiley interdisciplinary reviews. Nanomedicine and…
- 1 March 2011
This review has discussed both classically used small molecule based blood pool contrast agents and recently developed innovative nanoparticle-based strategies highlighting a number of successful molecular imaging examples.
Manganese-based MRI contrast agents: past, present and future.
Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets.
- D. Pan, S. Caruthers, G. Lanza
- Biology, ChemistryJournal of the American Chemical Society
- 24 June 2008
A complementary ability of nanobialys to incorporate chemotherapeutic compounds with greater than 98% efficiency and to retain more than 80% of these drugs after infinite sink dissolution, point to the theranostic potential of this platform technology.
Electrically-receptive and thermally-responsive paper-based sensor chip for rapid detection of bacterial cells.
Computed tomography in color: NanoK-enhanced spectral CT molecular imaging.
It is now well understood that the sensitive detection and quantification of small intravascular thrombus in coronary arteries with molecular imaging techniques could provide a direct metric to diagnose and risk stratify patients presenting with chest pain.
A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging
AbstractImaging sentinel lymph nodes (SLN) could provide us with critical information about the progression of a cancerous disease. Real-time high-resolution intraoperative photoacoustic imaging…
Molecular photoacoustic imaging of angiogenesis with integrin‐targeted gold nanobeacons
The combination of PAT and αvβ3‐GNBs offered sensitive and specific discrimination and quantification of angiogenesis in vivo, which may be clinically applicable to a variety of highly prevalent diseases, including cancer and cardiovascular disease.
An early investigation of ytterbium nanocolloids for selective and quantitative "multicolor" spectral CT imaging.
A novel molecular imaging agent based on ytterbium designed for use with spectral "multicolor" computed tomography (CT) exhibited excellent signal sensitivity, and the spectral CT technique uniquely discriminates the K-edge signal of Yb from calcium (bones).