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Early hepatic changes induced in rats by two hepatocarcinogenic organohalogen pesticides: bromopropylate and DDT.
TLDR
The present findings provide new evidence for the occurrence of dose-dependent abnormal mitoses (and c-mitoses) in the hepatocytes of the bromopropylate and DDT treated rats. Expand
Studies of early hepatocellular proliferation and peroxisomal proliferation in Wistar rats treated with herbicide diclofop.
TLDR
The results presented here demonstrate clearly that diclofop belongs to a class of rodent PPs. Expand
[The role of nuclear receptors in cytochrome P-450 induction by xenochemicals].
TLDR
Observations provide a rational explanation for the activation of multiple CYP gene classes by certain xenobiotics as well as the propensity for drug-drug interactions. Expand
[The effect of permethrin and DDT on the activity of cytochrome P-450 1A and 2B molecular forms in rat liver].
TLDR
The present results indicate that permethrin as well as DDT shows the ability to induce the phenobarbital-type of cytochrome P-4502B. Expand
Early hepatic changes in rats induced by permethrin in comparison with DDT.
TLDR
Perm may inhibit of phase G2 in the cell cycle and consequently it may suppress the cell entering into the stage of mitosis (M-phase) and the present findings provide evidence for the occurrence of abnormal mitoses in the hepatocytes of rats treated with DDT. Expand
Early hepatic changes induced by nuarimol in rats
TLDR
The increase in binuclear hepatocytes and signs of necrosis suggested that the hepatomitogenic effect of nuarimol reflected a regenerative response, which may simulate the proliferation caused by partial hepatectomy. Expand
The influence of fenarimol on dna synthesis and mitotic activity in rat liver
TLDR
The increase in binuclear hepatocytes and signs of necrosis suggested that the hepatomitogenic effect reflected a compensatory hyperplasia, and three single doses of fenarimol produced dose‐dependent liver growth, whereas five single doses caused no further increase in liver weight. Expand
Hepatocellular peroxisome proliferation and DNA synthesis in Wistar rats treated with herbicide fluazifop.
TLDR
It is concluded that fluazifop produces in male Wistar rats hepatomegaly due to cellular hypertrophy and can be classified as a weak rodent PPs. Expand
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