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Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein
Autophagy is a quality-control mechanism that helps to maintain cellular homeostasis by removing damaged proteins and organelles through lysosomal degradation. During autophagy, signaling events leadExpand
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Argonaute-2-null embryonic stem cells are retarded in self-renewal and differentiation
RNA interference (RNAi) pathways regulate self-renewal and differentiation of embryonic stem (ES) cells. Argonaute 2 (Ago2) is a vital component of RNA-induced silencing complex (RISC) and the onlyExpand
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Lack of Wdr13 Gene in Mice Leads to Enhanced Pancreatic Beta Cell Proliferation, Hyperinsulinemia and Mild Obesity
WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes toExpand
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κ-Casein-deficient mice fail to lactate
Acquisition of milk production capabilities by an ancestor of mammals is at the root of mammalian evolution. Milk casein micelles are a primary source of amino acids and calcium phosphate toExpand
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kappa-casein-deficient mice fail to lactate.
Acquisition of milk production capabilities by an ancestor of mammals is at the root of mammalian evolution. Milk casein micelles are a primary source of amino acids and calcium phosphate toExpand
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Isolation and characterization of a mouse embryonic stem cell line that contributes efficiently to the germ line
Embryonic stem (ES) cells have proven vital for introduction of pre-defined genetic modifications into mouse germ line. Here, we describe the isolation of a mouse ES cell line namely, R1.9 throughExpand
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