Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1‐receptor antagonist with negligible ability to penetrate the central nervous system
- E. Brown, R. Griffiths, C. A. Harvey, D. Owen
- Biology, MedicineBritish Journal of Pharmacology
- 1 March 1986
SK&F 93944 may have an advantage over classical histamine H1‐receptor antagonists in that it is likely to be devoid of untoward effects on the central nervous system.
Fructose prevents hypoxic cell death in liver.
- I. Anundi, J. King, D. Owen, H. Schneider, J. Lemasters, R. Thurman
- BiologyAmerican Journal of Physiology
- 1 September 1987
Fructose protects the liver against hypoxic cell death by the glycolytic production of ATP in the absence of oxygen by correlated well with cellular protection reflected by decreases in LDH release.
Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea] —A highly specific histamine H2-receptor agonist. Part 1. Pharmacology
- M. Parsons, D. Owen, C. Ganellin, G. J. Durant
- Biology, MedicineAgents and Actions
- 1 March 1977
Dimaprit should prove to be a very useful tool in studies examining the role of histamine in physiology and pathology, and the absence of marked cardiovascular effects at doses maximal for the stimulation of gastric acid secretion, could lead to this compound being of value as a diagnostic agent in the measurement of maximal acid secretory capacity.
Chapter Six – Actions of Histamine on the Heart and Vasculature
- R. Levi, D. Owen, J. Trzeciakowski
- Biology
- 1982
EVALUATION OF THE ROLE OF HISTAMINE H1 AND H2‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION
- D. Owen, E. Poy, D. Woodward, D. Daniel
- Medicine, BiologyBritish Journal of Pharmacology
- 1 August 1980
A combination of H1‐ and H2‐receptor antagonists appears to be more effective than either antagonist alone in reducing cutaneous inflammatory reactions involving histamine, and the permeability response to histamine is mediated solely by H1-receptors.
Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist
- R. Eden, B. Costall, A. Wright
- Biology, MedicinePharmacology, Biochemistry and Behavior
- 31 January 1991
Inotropic and electrophysiological effects of histamine on human ventricular heart muscle.
- L. Eckel, R. Gristwood, H. Nawrath, D. Owen, P. Satter
- Biology, MedicineJournal of Physiology
- 1 September 1982
Noradrenaline and isoprenaline produced similar responses to histamine, as did 8‐(4‐chlorphenylthio) cyclic AMP, consistent with the view that the effects of histamine as well as the beta‐adrenoceptor agonists on human ventricle, were associated with cyclicAMP mediated increases in calcium‐dependent slow inward current.
DIFFERENTIATION OF THE ROLES OF HISTAMINE Hr AND H2‐RECEPTORS IN THE MEDIATION OF THE EFFECTS OF HISTAMINE IN THE ISOLATED WORKING HEART OF THE GUINEA‐PIG
- S. B. Flynn, R. Gristwood, D. Owen
- Medicine, BiologyBritish Journal of Pharmacology
- 1 January 1979
The results indicate the important rôle of the histamine H2‐receptor in the mediation of the gross cardiac effects of histamine and also indicate that Histamine Hx‐receptors can mediate cardiac depression.
Histamine and histamine H1- and H2-receptor antagonists in acute inflammation.
- D. Owen, D. Woodward
- MedicineBiochemical Society Transactions
- 1 February 1980
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