D. Owen

Publications113
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Citations1,875
Highly Influential Citations22
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Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1‐receptor antagonist with negligible ability to penetrate the central nervous system
TLDR
SK&F 93944 may have an advantage over classical histamine H1‐receptor antagonists in that it is likely to be devoid of untoward effects on the central nervous system. Expand
Fructose prevents hypoxic cell death in liver.
TLDR
Fructose protects the liver against hypoxic cell death by the glycolytic production of ATP in the absence of oxygen by correlated well with cellular protection reflected by decreases in LDH release. Expand
Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist
TLDR
In rodents, ropinirole, like apomorphine, caused biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice with no tolerance to the latter after 14 days treatment, and these results support the continued clinical assessment of ro pinirole for the treatment of Parkinson's disease. Expand
Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea] —A highly specific histamine H2-receptor agonist. Part 1. Pharmacology
TLDR
Dimaprit should prove to be a very useful tool in studies examining the role of histamine in physiology and pathology, and the absence of marked cardiovascular effects at doses maximal for the stimulation of gastric acid secretion, could lead to this compound being of value as a diagnostic agent in the measurement of maximal acid secretory capacity. Expand
Histamine receptors in the cardiovascular system
Chapter Six – Actions of Histamine on the Heart and Vasculature
EVALUATION OF THE ROLE OF HISTAMINE H1 AND H2‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION
TLDR
A combination of H1‐ and H2‐receptor antagonists appears to be more effective than either antagonist alone in reducing cutaneous inflammatory reactions involving histamine, and the permeability response to histamine is mediated solely by H1-receptors. Expand
Inotropic and electrophysiological effects of histamine on human ventricular heart muscle.
TLDR
Noradrenaline and isoprenaline produced similar responses to histamine, as did 8‐(4‐chlorphenylthio) cyclic AMP, consistent with the view that the effects of histamine as well as the beta‐adrenoceptor agonists on human ventricle, were associated with cyclicAMP mediated increases in calcium‐dependent slow inward current. Expand
DIFFERENTIATION OF THE ROLES OF HISTAMINE Hr AND H2‐RECEPTORS IN THE MEDIATION OF THE EFFECTS OF HISTAMINE IN THE ISOLATED WORKING HEART OF THE GUINEA‐PIG
TLDR
The results indicate the important rôle of the histamine H2‐receptor in the mediation of the gross cardiac effects of histamine and also indicate that Histamine Hx‐receptors can mediate cardiac depression. Expand
HISTAMINE RELEASE FROM HUMAN RIGHT ATRIUM
TLDR
It is concluded that mast cell degranulation in human atrial tissue can cause sufficient release of histamine to modify the function of the heart. Expand
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