• Publications
  • Influence
The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium.
Aqueous humor outflow resistance is the primary determinant of intraocular pressure (IOP), and increased outflow resistance is the basis for elevated IOP associated with glaucoma. ExperimentalExpand
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Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes.
PURPOSE To understand how hydrodynamic and morphologic changes in the aqueous humor outflow pathway contribute to decreased aqueous humor outflow facility after acute elevation of intraocularExpand
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The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice.
PURPOSE To determine the connections between the ciliary muscle (CM), trabecular meshwork (TM), and Schlemm's canal (SC) and their innervations that allows CM contraction (by pilocarpine) toExpand
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eNOS, a pressure-dependent regulator of intraocular pressure.
PURPOSE Pathology in the primary drainage pathway for aqueous humor in the eye is responsible for ocular hypertension, the only treatable risk factor in patients with glaucoma. Unfortunately, theExpand
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The mechanism of increasing outflow facility during washout in the bovine eye.
PURPOSE To investigate the relationship between outflow facility and separation between the inner wall of the aqueous plexus and the juxtacanalicular connective tissue (JCT) during washout in theExpand
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Altered mechanobiology of Schlemm’s canal endothelial cells in glaucoma
  • D. Overby, E. Zhou, +13 authors M. Johnson
  • Medicine, Materials Science
  • Proceedings of the National Academy of Sciences
  • 8 September 2014
Significance Glaucoma is a leading cause of blindness. The elevated intraocular pressure characteristic of many cases of glaucoma is attributable to increased resistance to aqueous humor outflow.Expand
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Outflow physiology of the mouse eye: pressure dependence and washout.
PURPOSE Mice are commonly used in glaucoma research, but relatively little is known about aqueous outflow dynamics in the species. To facilitate future use of the mouse as a model of aqueous humorExpand
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Unconventional aqueous humor outflow: A review.
Aqueous humor flows out of the eye primarily through the conventional outflow pathway that includes the trabecular meshwork and Schlemm's canal. However, a fraction of aqueous humor passes through anExpand
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A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy.
Conventional transmission electron microscopic (TEM) images of the juxtacanalicular tissue (JCT) region of the trabecular meshwork (TM) show flow passages that are much too large to generateExpand
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Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.
Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow resistance and thus intraocular pressure; andExpand
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