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Determination of the effect of tridiphane on the pharmacokinetics of [14C]-atrazine following oral administration to male Fischer 344 rats.
The absorption, distribution, metabolism and excretion of [14C]-atrazine was studied in male Fischer 344 rats administered a 30 mg [14C]-atrazine/kg of body weight oral dose with or withoutExpand
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Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products
  • D. Osborne
  • Chemistry, Medicine
  • Journal of cosmetic dermatology
  • 1 December 2011
Background  The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment ofExpand
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Small Angle X-Ray diffraction Patterns of Stratum Corneum and a Model Structure for Its Lip ids
ABSTRACT The structure of the lipid part of stratum corneum,was shown to be a lamellar liquid crystal in accordance with earlier suagestions by Elias et al. The main structure forming compound wasExpand
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Microemulsions as topical drug delivery vehicles: in‐vitro transdermal studies of a model hydrophilic drug
Abstract— Microemulsions with a 58:42 weight ratio of dioctyl sodium sulphosuccinate: octanol and containing 15, 35, and 68% water have been tested for their ability to transport glucose across humanExpand
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Cremophor-free intravenous microemulsions for paclitaxel I: formulation, cytotoxicity and hemolysis.
Two cremophor-free microemulsions, lecithin:butanol:myvacet oil:water (LBMW) and capmul:myvacet oil:water (CMW) for paclitaxel (PAC) were developed for intravenous (i.v.) administration. SixExpand
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Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures
AbstractA heightened interest in (trans)dermal delivery is in part driven by the need to improve the existing skin therapies and also the demand for alternative routes of administration, notably forExpand
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Pharmacokinetic profiles in rats after intravenous, oral, or dermal administration of dapsone.
Dapsone is a potent anti-inflammatory and antibacterial agent that has been used extensively in the oral treatment of leprosy and dermatitis herpetiformis. This study compared the pharmacokineticExpand
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Abstract Ternary and Pseudo-ternary phase behavior of the system water/hexadecane/dioctyl sodium sulfosuccinate (DSS)/sorbitan laurate has been determined. The microemulsion region of thisExpand
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Roflumilast Cream Improves Signs and Symptoms of Plaque Psoriasis: Results from a Phase 1/2a Randomized, Controlled Study.
Background: Roflumilast cream (ARQ-151) is a highly potent, selective phosphodiesterase-4 inhibitor in development for once-daily topical treatment of chronic plaque psoriasis. Objectives: To assessExpand
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