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Receptor Specificity of the Fibroblast Growth Factor Family*
  • D. Ornitz, Jingsong Xu, +5 authors M. Goldfarb
  • Biology, Medicine
    The Journal of Biological Chemistry
  • 21 June 1996
It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.
Fibroblast growth factors
A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
The Fibroblast Growth Factor signaling pathway
  • D. Ornitz, N. Itoh
  • Biology, Medicine
    Wiley interdisciplinary reviews. Developmental…
  • 13 March 2015
Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
A twist code determines the onset of osteoblast differentiation.
It is shown that Twist proteins transiently inhibit Runx2 function during skeletogenesis, which means that relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation.
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
To address the role of FGFR2 in normal bone development, a conditional gene deletion approach was adopted and robust expression of CRE in mesenchymal condensations giving rise to both osteoblast and chondrocyte lineages.
Evolution of the Fgf and Fgfr gene families.
The expansion of the Fgf and Fgfr gene families has enabled this signaling system to acquire functional diversity and, therefore, an almost ubiquitous involvement in developmental and physiological processes.
Receptor Specificity of the Fibroblast Growth Factor Family
This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
Findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction.
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Twist Regulates Cytokine Gene Expression through a Negative Feedback Loop that Represses NF-κB Activity
An evolutionarily conserved signaling circuit in which twist proteins regulate cytokine signaling by establishing a negative feedback loop that represses the NF-kappaB-dependent cytokine pathway is revealed.