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Receptor Specificity of the Fibroblast Growth Factor Family*
- D. Ornitz, J. Xu, +5 authors M. Goldfarb
- Biology, Medicine
- The Journal of Biological Chemistry
- 21 June 1996
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are… Expand
The Fibroblast Growth Factor signaling pathway
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs).… Expand
Fibroblast growth factors
SummaryFibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF… Expand
Receptor Specificity of the Fibroblast Growth Factor Family
- Xiuqin Zhang, O. Ibrahimi, S. Olsen, H. Umemori, M. Mohammadi, D. Ornitz
- Biology, Medicine
- Journal of Biological Chemistry
- 9 June 2006
In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The spatial and temporal… Expand
A twist code determines the onset of osteoblast differentiation.
Runx2 is necessary and sufficient for osteoblast differentiation, yet its expression precedes the appearance of osteoblasts by 4 days. Here we show that Twist proteins transiently inhibit Runx2… Expand
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
Human craniosynostosis syndromes, resulting from activating or neomorphic mutations in fibroblast growth factor receptor 2 (FGFR2), underscore an essential role for FGFR2 signaling in skeletal… Expand
Evolution of the Fgf and Fgfr gene families.
Fibroblast growth factors (Fgfs) and Fgf receptors (Fgfrs) comprise a signaling system that is conserved throughout metazoan evolution. Twenty-two Fgfs and four Fgfrs have been identified in humans… Expand
Twist Regulates Cytokine Gene Expression through a Negative Feedback Loop that Represses NF-κB Activity
During Drosophila embryogenesis, the dorsal transcription factor activates the expression of twist, a transcription factor required for mesoderm formation. We show here that the mammalian twist… Expand
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
The role of low affinity, heparin-like binding sites for basic fibroblast growth factor (bFGF) was investigated in CHO cells mutant in their metabolism of glycosaminoglycans. Heparan… Expand
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. To explore functions of FGF/FGFR2 signals in… Expand