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Bone marrow cells regenerate infarcted myocardium
It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease. Expand
Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts have failed to reconstitute healthy myocardium and coronary vessels integrated structurally andExpand
Cardiomyogenesis in the Adult Human Heart
The findings indicate that the human heart has a significant growth reserve and replaces its myocyte and nonmyocyte compartment several times during the course of life. Expand
Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.
Properties of definitive HSC are coexistent, but not equal in number, in the murine yolk sac and P-Sp prior to fetal liver colonization, and 37-fold more CD34+c-Kit+ cells reside in the day 9 yolks than in the P-sp. Expand
Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
In vivo findings demonstrate the capacity of highly enriched Lin− c‐kit+ adult bone marrow cells to acutely regenerate functional myocardium within an infarcted region. Expand
The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
The fusion gene Cbfb - MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
Stem cells for myocardial regeneration.
To further understand the role of stem cells in regeneration, it is incumbent on us to develop instrumentation and technologies to monitor myocardial repair over time in large animal models and to identify the environmental cues needed for stem cell trafficking and define the genetic and cellular mechanisms that initiate transdifferentiation. Expand
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.
AMD3100-mobilized CD34(+) cells represent an alternative source of hematopoietic stem cells for clinical stem cell transplantation and genetic manipulation with integrating retroviral vectors, suggesting fundamental differences in the mechanism of AMD3100mediated and G-CSF-mediated hematOPoietIC stem cell mobilization. Expand
Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.
There appears to be a critical dose-dependent effect of GATA-2 on blood cell differentiation in that downregulation of Gata-2 expression is necessary for stem cells to contribute to hematopoiesis in vivo. Expand
Bone marrow stem cells regenerate infarcted myocardium
This research is focused on the capacity of BMSC to form new cardiac myocytes and coronary vessels following an induced myocardial infarct in adult mice and results in improved cardiac function and survival. Expand