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Bone marrow cells regenerate infarcted myocardium
Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deterioratesExpand
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Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts have failed to reconstitute healthy myocardium and coronary vessels integrated structurally andExpand
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Cardiomyogenesis in the Adult Human Heart
Rationale: The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by different laboratories varies from none toExpand
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Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.
The site of origin of lymphohematopoietic stem cells (HSC) that initiate definitive blood cell production in the murine fetal liver is controversial. Contrary to reports that the preliver yolk sacExpand
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Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
Abstract: Occlusion of the anterior descending left coronary artery leads to ischemia, infarction, and loss of function in the left ventricle. We have studied the repair of infarcted myocardium inExpand
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Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.
The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, aExpand
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The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
The fusion gene Cbfb - MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
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Bone marrow stem cells regenerate infarcted myocardium
Abstract: Heart disease is the leading cause of death in the United States for both men and women. Nearly 50% of all cardiovascular deaths result from coronary artery disease. Occlusion of the leftExpand
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Stem cells for myocardial regeneration.
Stem cells are being investigated for their potential use in regenerative medicine. A series of remarkable studies suggested that adult stem cells undergo novel patterns of development by a processExpand
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AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.
AMD3100, a bicyclam antagonist of the chemokine receptor CXCR4, has been shown to induce rapid mobilization of CD34(+) hematopoietic cells in mice, dogs, and humans, offering an alternative to G-CSFExpand
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