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Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14
It is shown that USP14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin–protein conjugates both in vitro and in cells. Expand
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
It is proposed that mutual antagonism between the APC and the SAC yields a positive feedback loop that amplifies the ability of TAME to induce mitotic arrest. Expand
D-Amino Acids Govern Stationary Phase Cell Wall Remodeling in Bacteria
It is found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures and appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall. Expand
Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora
These results conform to a model of selection-driven pathway fixation occurring subsequent to gene acquisition and provide a rare example in which demonstrable physiological traits have been correlated to the fine-scale phylogenetic architecture of an environmental bacterial community. Expand
Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture.
Emericellamides A and B show modest antibacterial activities against methicillin-resistant Staphylococcus aureus with MIC values of 3.8 and 6.0 microM, respectively. Expand
Bacterial Protection of Beetle-Fungus Mutualism
It is shown that southern pine beetles use symbiotic fungi to help overcome host-tree defenses and to provide nutrition for their larvae, and that this beetle-fungal mutualism is chemically mediated by a bacterially produced polyunsaturated peroxide. Expand
Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.
Fungus-growing ants engage in mutualistic associations with both the fungus they cultivate for food and actinobacteria that produce selective antibiotics to defend that fungus from specialized fungal parasites, and one such system is analyzed at the molecular level. Expand
Chemical Analyses of Wasp-Associated Streptomyces Bacteria Reveal a Prolific Potential for Natural Products Discovery
The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Expand
Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin.
The novel amino acid residue 2-amino-3,5-dimethylhex-4-enoic acid in the cyclomarin series was shown by bioinformatics and stable isotope experiments to derive from a new pathway involving condensation of isobutyraldehyde and pyruvate followed by S-adenosylmethionine methylation. Expand
Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition.
The induction of biosynthesis of four new diterpenoids was observed following the addition of a marine alpha-proteobacterium to an established culture of the marine-derived fungus Libertella sp. TheExpand