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Global biogeographic sampling of bacterial secondary metabolism
Recent bacterial (meta)genome sequencing efforts suggest the existence of an enormous untapped reservoir of natural-product-encoding biosynthetic gene clusters in the environment. Here we use the…
Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifolia.
A total of 39 endophytic fungi have been isolated from Viguiera arenaria and Tithonia diversifolia, both collected in São Paulo State, Brazil, and nectriapyrone showed relevant cytotoxic activity against both human T leukemia and melanoma tumor cell lines.
Diketopiperazines produced by endophytic fungi found in association with two Asteraceae species.
Tannin composition of barbatimão species.
Antibiotics: therapeutic importance and perspectives for the discovery and development of new agents
Azaphilones from the endophyte Chaetomium globosum.
- W. Borges, Gabriela Mancilla, D. O. Guimarães, R. Durán-Patrón, I. G. Collado, M. T. Pupo
- ChemistryJournal of natural products
- 6 May 2011
The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses and the antibiotic activity of the compounds was evaluated using an in vivo Caenorhabditis elegans infection model.
A simple method for the quantitative analysis of tyrosol by HPLC in liquid Czapek cultures from endophytic fungi.
®ODS (250 × 4,6 mm, 5 µm) a 25 °C foi utilizada. Extracao liquido-liquido de 0,5 mL do meio (pH 7,0) com acetato de etila e injecao de 20 µL apos concentracao do solvente sob ar comprimido originou…
Phytochemical Study of Tapirira guianensis Leaves Guided by Vasodilatory and Antioxidant Activities
The results show that MET-induced vasodilation was dependent on NO/cGMP; and that the PI3K/Akt pathway seems to be the main route involved in eNOS activation.
Meroterpenes isolated from the endophytic fungus Guignardia mangiferae
Apoptosis Caused by Triterpenes and Phytosterols and Antioxidant Activity of an Enriched Flavonoid Extract from Passiflora mucronata.
- Isabel C. V. da Silva, G. Kaluđerović, I. Leal
- Medicine, ChemistryAnti-cancer agents in medicinal chemistry
- 23 January 2019
P. mucronata hexane fraction showed promising cytotoxic effect against cancer cell lines, and stigmasterol contributes to this activity, inducing apoptosis of these cells.