D. O'Kane

Publications148
h-index36
Citations4,376
Highly Influential Citations137
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Comparison of screening methods in the detection of bladder cancer.
TLDR
Urinary telomerase had the highest combination of sensitivity and specificity for bladder cancer screening in these patients and was the strongest predictor with superior accuracy in patients with grade 1 and noninvasive tumors (pTa), and extremely useful in patientsWith carcinoma in situ.
A comparison of cytology and fluorescence in situ hybridization for the detection of urothelial carcinoma.
TLDR
The sensitivity of FISH for the detection of urothelial carcinoma is superior to that of cytology, and the specificity of Fish and cytology for uroclinical carcinoma are not significantly different.
SLC6A4 variation and citalopram response
TLDR
It is suggested that multiple variations in the SLC6A4 gene are associated with remission in white non‐Hispanic depressed adults treated with citalopram, and the mechanism of action of these variants remains to be determined.
Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.
TLDR
Although a correlation between steady-state warfarin dose and allelic variants of CYP2C9 and VKORC1 has been demonstrated by many previous reports, it is reconfirmed in this report that an association was seen between allelic variant and steady- state warFarin dose.
CYP2C19 variation and citalopram response
TLDR
Variations in CYP2C19 were associated with tolerance and remission in a large sample of White non-Hispanic patients treated with citalopram, despite several limitations including the lack of serum drug levels.
Endothelial Nitric Oxide Synthase Gene Polymorphisms Predict Susceptibility to Aneurysmal Subarachnoid Hemorrhage and Cerebral Vasospasm
TLDR
Genetic information such as this, which can be obtained expeditiously at the time of diagnosis, may be used as a helpful adjunct to other clinical information aimed at predicting and favorably modifying the clinical course of persons with intracranial aneurysms.
A comparison of BTA stat, hemoglobin dipstick, telomerase and Vysis UroVysion assays for the detection of urothelial carcinoma in urine.
TLDR
UroVysion is a promising new assay for the detection of urothelial carcinoma in urine specimens that is statistically significantly more sensitive than the telomerase assay and more specific than hemoglobin dipstick testing.
Diagnostic Performance of Cyst Fluid Carcinoembryonic Antigen and Amylase in Histologically Confirmed Pancreatic Cysts
TLDR
Cyst fluid CEA and amylase levels are suggestive but not diagnostic in differentiating PCLs, and unlike CEA, amyl enzyme may help differentiate benign from malignant mucinous cysts.
Effect of Cytochrome P450 Enzyme Polymorphisms on Pharmacokinetics of Venlafaxine
TLDR
Both CYP2D6 and CYC19 genotypes should be considered when using pharmacogenomic information for venlafaxine dose alterations, due to their influence on the total concentration of the active compounds venl Lafaxine and ODV.
CYP2D6: novel genomic structures and alleles
TLDR
The findings suggest that the recombination events responsible for CYP2D6 duplications and multiplications are because of mechanisms other than interchromosomal crossover during meiosis.
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