D. O'Connor

Publications475
h-index71
Citations17,830
Highly Influential Citations489
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The chromogranin-secretogranin family.
The members of the chromogranin–secretogranin family of peptide hormones, biogenic amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system and a variety of neurons.… Expand
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Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension.
The pore-forming alpha-subunit, Kv1.5, forms functional voltage-gated K(+) (Kv) channels in human pulmonary artery smooth muscle cells (PASMC) and plays an important role in regulating membrane… Expand
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Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
Catecholamine secretory vesicle core proteins (chromogranins) contain an activity that inhibits catecholamine release, but the identity of the responsible peptide has been elusive. Size-fractionated… Expand
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Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog.
The secretory prohormone chromogranin A (CHGA) is overexpressed in essential hypertension, a complex trait with genetic predisposition, while its catecholamine release-inhibitory fragment catestatin… Expand
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Dopamine β-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation
Levels of the enzyme dopamine β-hydroxylase (DβH) in the plasma and cerebrospinal fluid (CSF) are closely related biochemical phenotypes. Both are under strong genetic control. Linkage and… Expand
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Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk.
IMPORTANCE Posttraumatic stress disorder (PTSD) has been associated in cross-sectional studies with peripheral inflammation. It is not known whether this observed association is the result of PTSD… Expand
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Genetic influences on endometriosis in an Australian twin sample. sueT@qimr.edu.au.
OBJECTIVE To investigate the prevalence of and twin pair concordance for endometriosis. DESIGN A questionnaire survey incorporating validation. SETTING An Australia-wide volunteer sample of… Expand
  • 255
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Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A
Chromogranin A (CgA) is the index member of the chromogranin/secretogranin (or `granin') family of regulated secretory proteins that are ubiquitously distributed in amine- and peptide-containing… Expand
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Secretion of chromogranin A by peptide-producing endocrine neoplasms.
Chromogranin A, the protein that is co-stored and co-released with catecholamines from the adrenal medulla, has recently been identified in a variety of human endocrine tissues, both normal and… Expand
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Mechanism of cardiovascular actions of the chromogranin A fragment catestatin in vivo
Catestatin (bovine chromogranin A(344-364); RSMRLSFRARGYGFRGPGLQL), reduces catecholamine secretion from chromaffin cells in vitro. We investigated the effects of this peptide on catecholamine… Expand
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