The chromogranin-secretogranin family.
The members of the chromogranin–secretogranin family of peptide hormones, biogenic amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system and a variety of neurons.…
Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons.
Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension.
- C. V. Remillard, Donna D. Tigno, J. Yuan
- BiologyAmerican Journal of Physiology - Cell Physiology
- 1 May 2007
It is reported that overexpression of the Kv1.5 channel gene (KCNA5) in human PASMC and other cell lines produced a 15-pS single channel current and a large whole cell current that was sensitive to 4-aminopyridine, and novel SNPs in the promoter and translated regions of KCNA5 are present in IPAH patients.
Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog.
Loss of the physiological "brake" catestatin in Chga mice coupled with dysregulation of transmitter storage and release may act in concert to alter autonomic control of the circulation in vivo, eventuating in hypertension.
Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk.
IMPORTANCE Posttraumatic stress disorder (PTSD) has been associated in cross-sectional studies with peripheral inflammation. It is not known whether this observed association is the result of PTSD…
Dopamine β-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation
The results confirm thatDBH is a major quantitative trait locus for plasma DβH activity, and provide the first direct evidence that DBH also influences CSF D βH levels.
Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene
Secretion of chromogranin A by peptide-producing endocrine neoplasms.
The elevation of plasma chromogranin A in subjects with endocrine tumors suggests that their neoplasms co-release chromog Granin A along with the usual resident hormone of the tumor, that these neoplasm could be characterized as "chromogran inomas," and that measurement of plasma ChromogranIn A may be a useful diagnostic procedure in subjectsWith endocrine tumor groups, especially multiple endocrine neoplasia.
Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A
- L. Taupenot, K. L. Harper, N. Mahapatra, R. Parmer, S. Mahata, D. O'Connor
- BiologyJournal of Cell Science
- 15 December 2002
It is established that a CgA-GFP fusion protein expressed in neuroendocrine PC12 cells is trafficked to the dense core secretory granule and thereby sorted to the regulated pathway for exocytosis and the data reveal for the first time that the CGA77-115 domain of the mature protein may be necessary (though perhaps not sufficient) for trafficking C gA into the regulated pathways of secretion.