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Hepatitis C virus drug resistance and immune‐driven adaptations: Relevance to new antiviral therapy
The efficacy of specifically targeted anti‐viral therapy for hepatitis C virus (HCV) (STAT‐C), including HCV protease and polymerase inhibitors, is limited by the presence of drug‐specific viral… Expand
Accumulation of mitochondrial DNA mutations in human immunodeficiency virus-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors.
- A. Martin, E. Hammond, +7 authors S. Mallal
- Biology, Medicine
- American journal of human genetics
- 1 March 2003
Nucleoside reverse-transcriptase inhibitor (NRTI) therapy for human immunodeficiency virus (HIV) infection has been associated with mitochondrial DNA (mtDNA) polymerase-gamma inhibition and… Expand
Human immunodeficiency virus treatment-induced adipose tissue pathology and lipoatrophy: prevalence and metabolic consequences.
- E. Hammond, E. McKinnon, D. Nolan
- Clinical infectious diseases : an official…
- 1 September 2010
BACKGROUND Lipoatrophy and metabolic complications of treatment of human immunodeficiency virus (HIV) infection may share common associations with adipose tissue pathology and inflammation. To… Expand
Tabloidisation Revisited: The Regeneration of Journalism in Conditions of 'Advanced Liberalism'
- D. Nolan
- Political Science
For the last two decades, the problem of how to understand contemporary transformations in journalism has frequently revolved around concerns about an alleged 'tabloidisation', that has not only… Expand
Tissue-Specific Associations Between Mitochondrial DNA Levels and Current Treatment Status in HIV-Infected Individuals
- C. Cherry, D. Nolan, +6 authors S. Wesselingh
- Biology, Medicine
- Journal of acquired immune deficiency syndromes
- 1 August 2006
Background: Tissue mitochondrial DNA (mtDNA) levels have been proposed as a marker of nucleoside analouge reverse transcriptase inhibitor (NRTI) toxicity. However, clinical studies have yielded… Expand
Assessing the contribution of ART, HIV and host factors to adipose tissue changes occurring in HIV-infected individuals: Risk profile for lipoatrophy
Objectives: For HIV-infected individuals receiving antiretroviral therapy (ART), the development of lipoatrophy significantly impacts clinical management. To identify critical risk factors for… Expand
Carriage of HLA-B*5701 and a haplotypic Hsp70-Hom variant is associated with a Class I MHC-restricted hypersensitivity response to abacavir
Background: Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use has a significant genetic component. We have shown that the presence of HLA-B*5701… Expand
Future challenges of changing agricultural equipment
This report investigates the policy challenges presented by the operation of agricultural vehicles on public roads in Australia and New Zealand. The research identifies agricultural industry trends… Expand
‘We are not North Korea’: propaganda and professionalism in the People’s Republic of China
This article draws on an empirical analysis of the testimonies of Chinese journalists to (re)consider the nature of professionalism in contemporary Chinese journalism. We draw on earlier work by a… Expand