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Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae).
The results suggest a peripheral and central analgesic activities as well as an anticonvulsant effect of the leaves of Kalanchoe crenata. Expand
Anti-inflammatory activities of two flavanones, sigmoidin A and sigmoidin B, from Erythrina sigmoidea.
Two prenylated flavanones isolated from Erythrina sigmoidea Hua were studied for their ability to inhibit the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and arachidonic acid metabolism and the results indicate that the compounds have different mechanisms of action depending on whether one or two preNyl groups are present in ring B. Expand
Anti-inflammatory and analgesic properties of the stem bark extracts of Erythrophleum suaveolens (Caesalpiniaceae), Guillemin & Perrottet.
Findings suggest that extracts of the bark of Erythrophleum suaveolens possess potent anti-inflammatory and analgesic property and that the procyanidins lead to the observable pharmacological effects. Expand
Structure-oriented UHPLC-LTQ Orbitrap-based approach as a dereplication strategy for the identification of isoflavonoids from Amphimas pterocarpoides crude extract.
A new structure-oriented approach based on fast UHPLC-high-resolution (HR)MS and HRMS/MS methodologies for the identification of isoflavonoids in crude extracts is developed to assist dereplication procedures, to decrease the laborious isolation steps and orient the focused isolation of compounds of interest. Expand
Sesquiterpene lactone and friedelane derivative from drypetes molunduana.
A new sesquiterpene lactone, drypemolundein A and a new friedelane derivative, drypemolundein B, along with seven known compounds have been isolated from the whole stems of Drypetes molunduana PaxExpand
Estrogenic properties of naturally occurring prenylated isoflavones in U2OS human osteosarcoma cells: Structure–activity relationships
The results show that a substitution at position 3' together with a 7-methoxy substitution on the genistein skeleton is associated with a statistically significant activation of the ERalpha- and ERbeta-dependent reporter gene expression in U2OS cells starting from 0.1nM, demonstrating an "exclusive ER beta-selectivity" in U 2OS human osteosarcoma cells. Expand
Erythroidine alkaloids: a novel class of phytoestrogens.
This is the first time that an estrogenic profile is reported for erythroidine alkaloids, potentially a new class of phytoestrogens, for E. poeppigiana. Expand
The hydro-ethanolic extract of Acacia seyal (Mimosaceae) stem barks induced death in an ER-negative breast cancer cell line by the intrinsic pathway of apoptosis and inhibited cell migration.
Results demonstrate that A. seyal extract induced its antitumor effects mainly by interference in metastasis related events, by triggering apoptosis through a ROS-mediated mitochondrial pathway. Expand
Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii.
In vivo, erycristagallin significantly reduced the chronic inflammation and leukocyte infiltration induced by repeated application of TPA and may be based on its capacity to inhibit the arachidonic acid metabolism via the 5-lipoxygenase pathway. Expand
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
The prenylisoflavone warangalone, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively. Expand