• Publications
  • Influence
Microbial heavy-metal resistance
  • D. Nies
  • Chemistry, Medicine
  • Applied Microbiology and Biotechnology
  • 30 May 1999
Abstract We are just beginning to understand the metabolism of heavy metals and to use their metabolic functions in biotechnology, although heavy metals comprise the major part of the elements in theExpand
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  • 181
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Alcaligenes eutrophus CH34 is a facultative chemolithotroph with plasmid-bound resistance to heavy metals.
Alcaligenes eutrophus strain CH34, which was isolated as a bacterium resistant to cobalt, zinc, and cadmium ions, shares with A. eutrophus strain H16 the ability to grow lithoautotrophically onExpand
  • 713
  • 103
Efflux-mediated heavy metal resistance in prokaryotes.
  • D. Nies
  • Biology, Medicine
  • FEMS microbiology reviews
  • 1 June 2003
What makes a heavy metal resistant bacterium heavy metal resistant? The mechanisms of action, physiological functions, and distribution of metal-exporting proteins are outlined, namely: CBA effluxExpand
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Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli.
The cus determinant of Escherichia coli encodes the CusCFBA proteins that mediate resistance to copper and silver by cation efflux. CusA and CusB were essential for copper resistance, and CusC andExpand
  • 393
  • 35
The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.
A previous report identified and classified a small family of gram-negative bacterial drug and heavy metal efflux permeases, now commonly referred to as the RND family (TC no. 2.6). We here show thatExpand
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Insights into genome plasticity and pathogenicity of the plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence.
The gram-negative plant-pathogenic bacterium Xanthomonas campestris pv. vesicatoria is the causative agent of bacterial spot disease in pepper and tomato plants, which leads to economically importantExpand
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Ion efflux systems involved in bacterial metal resistances
  • D. Nies, S. Silver
  • Biology, Medicine
  • Journal of Industrial Microbiology
  • 1 February 1995
SummaryStudying metal ion resistances gives us important insights into environmental processes and provides an understanding of basic living processes. This review concentrates on bacterial effluxExpand
  • 419
  • 18
Resistance to cadmium, cobalt, zinc, and nickel in microbes.
  • D. Nies
  • Biology, Medicine
  • Plasmid
  • 1992
The divalent cations of cobalt, zinc, and nickel are essential nutrients for bacteria, required as trace elements at nanomolar concentrations. However, at micro- or millimolar concentrations, Co2+,Expand
  • 322
  • 15
New genes involved in chromate resistance in Ralstonia metallidurans strain CH34
Chromate resistance in Ralstonia metallidurans CH34 is based on chromate efflux catalyzed by ChrA efflux pumps. The bacterium harbors two chromate resistance determinants, the previously known chr(1)Expand
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ZitB (YbgR), a member of the cation diffusion facilitator family, is an additional zinc transporter in Escherichia coli.
The Escherichia coli zitB gene encodes a Zn(II) transporter belonging to the cation diffusion facilitator family. ZitB is specifically induced by zinc. ZitB expression on a plasmid renderedExpand
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