D. Newcombe

Publications56
h-index20
Citations1,058
Highly Influential Citations9
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Classification of back muscle impairment based on the surface electromyographic signal.
A surface electromyographic (EMG) procedure for classifying muscle impairments in persons with low back pain (LBP) is described. The procedure was studied using a device, the Back Analysis System… Expand
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Human monocyte carboxylesterase. Purification and kinetics.
Human peripheral blood monocytes were isolated by density gradient centrifugation and purified by counterflow centrifugation elutriation. Membrane-localized carboxylesterase (CBE) was extracted with… Expand
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The role of the human synovial fibroblast in monosodium urate crystal-induced synovitis.
Human synovial fibroblasts (HSF) have been cultured to identify and quantitate arachidonate metabolites released after exposure to monosodium urate (MSU) crystals. These crystals caused a significant… Expand
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Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers.
Human pulmonary macrophages (PAM) recovered from young cigarette smokers and from age- and sex-matched subjects who had never smoked were used to investigate arachidonic acid metabolism. The uptake… Expand
  • 51
Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.
The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine.… Expand
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Hydrocortisone inhibition of the bradykinin activation of human synovial fibroblasts.
Human synovial fibroblasts in culture respond to bradykinin with a 20-fold increment in intracellular cyclic AMP concentrations, however bradykinin does not directly activate adenylate cyclase… Expand
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Glucocorticoid inhibition of zymosan-induced arachidonic acid release by rat alveolar macrophages.
The phospholipase-dependent liberation of arachidonic acid (AA) from membrane phospholipids has been proposed as the rate-limiting step in the synthesis of bioactive AA metabolites, which play an… Expand
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Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism.
Resting rat pulmonary alveolar macrophages exposed to acrolein were stimulated to synthesize and release thromboxane B2 and prostaglandin E2 in a dose-dependent manner. Zymosan-activated pulmonary… Expand
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The effect of anti-inflammatory agents on human synovial fibroblast prostaglandin synthetase.
Human synovial fibroblast prostaglandin synthetase activity is inhibited by many different non-steroidal anti-inflammatory agents. Aspirin, indomethacin and phenylbutazone significantly inhibit both… Expand
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Cartilage cyclic nucleotide phosphodiesterase: inhibition by anti-inflammatory agents.
Abstract Soluble 3′,5′-nucleotide phosphodiesterase (PDE) activity is described in chicken epiphyseal and articular cartilage. Kinetic studies of these enzymes demonstrate a high and low K m for the… Expand
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