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Classification of back muscle impairment based on the surface electromyographic signal.
- S. Roy, C. D. De Luca, +5 authors J. Jabre
- Journal of rehabilitation research and…
- 1 October 1997
A surface electromyographic (EMG) procedure for classifying muscle impairments in persons with low back pain (LBP) is described. The procedure was studied using a device, the Back Analysis System… Expand
Human monocyte carboxylesterase. Purification and kinetics.
Human peripheral blood monocytes were isolated by density gradient centrifugation and purified by counterflow centrifugation elutriation. Membrane-localized carboxylesterase (CBE) was extracted with… Expand
The role of the human synovial fibroblast in monosodium urate crystal-induced synovitis.
Human synovial fibroblasts (HSF) have been cultured to identify and quantitate arachidonate metabolites released after exposure to monosodium urate (MSU) crystals. These crystals caused a significant… Expand
Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers.
Human pulmonary macrophages (PAM) recovered from young cigarette smokers and from age- and sex-matched subjects who had never smoked were used to investigate arachidonic acid metabolism. The uptake… Expand
Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.
- D. Newcombe, C. Ciosek, Y. Ishikawa, J. V. Fahey
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 August 1975
The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine.… Expand
Hydrocortisone inhibition of the bradykinin activation of human synovial fibroblasts.
Human synovial fibroblasts in culture respond to bradykinin with a 20-fold increment in intracellular cyclic AMP concentrations, however bradykinin does not directly activate adenylate cyclase… Expand
Glucocorticoid inhibition of zymosan-induced arachidonic acid release by rat alveolar macrophages.
- M. Peters-Golden, J. Bathon, R. Flores, F. Hirata, D. Newcombe
- Biology, Medicine
- The American review of respiratory disease
- 1 November 1984
The phospholipase-dependent liberation of arachidonic acid (AA) from membrane phospholipids has been proposed as the rate-limiting step in the synthesis of bioactive AA metabolites, which play an… Expand
Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism.
- C. C. Grundfest, J. Chang, D. Newcombe
- Chemistry, Medicine
- Biochimica et biophysica acta
- 14 October 1982
Resting rat pulmonary alveolar macrophages exposed to acrolein were stimulated to synthesize and release thromboxane B2 and prostaglandin E2 in a dose-dependent manner. Zymosan-activated pulmonary… Expand
The effect of anti-inflammatory agents on human synovial fibroblast prostaglandin synthetase.
Human synovial fibroblast prostaglandin synthetase activity is inhibited by many different non-steroidal anti-inflammatory agents. Aspirin, indomethacin and phenylbutazone significantly inhibit both… Expand
Cartilage cyclic nucleotide phosphodiesterase: inhibition by anti-inflammatory agents.
Abstract Soluble 3′,5′-nucleotide phosphodiesterase (PDE) activity is described in chicken epiphyseal and articular cartilage. Kinetic studies of these enzymes demonstrate a high and low K m for the… Expand