Classification of back muscle impairment based on the surface electromyographic signal.
- S. Roy, C. D. De Luca, J. Jabre
- MedicineJournal of rehabilitation research and…
- 1 October 1997
A series of studies are described that have been useful in developing an automated procedure for identifying back muscle impairment by comparing individual test results to a normative database and it is found that the functions can distinguish individuals with and without LBP with an accuracy of approximately 90%.
Human monocyte carboxylesterase. Purification and kinetics.
- A. Saboori, D. Newcombe
- BiologyJournal of Biological Chemistry
- 15 November 1990
X-Linked Recessive Inheritance of a Syndrome of Mental Retardation With Hyperuricemia
- Samuel L. Shapiro, G. Sheppard, F. Dreifuss, D. Newcombe
- Biology, MedicineProceedings of the Society for Experimental…
- 1 June 1966
Summary A pedigree of a heritable metabolic disorder of uric acid overproduction indicated an x-linked recessive mode of inheritance. Affected members had mental and motor retardation, a gravel-like…
The role of the human synovial fibroblast in monosodium urate crystal-induced synovitis.
- F. Wigley, I. T. Fine, D. Newcombe
- Biology, MedicineJournal of Rheumatology
- 1 August 1983
Human synovial fibroblasts have been cultured to identify and quantitate arachidonate metabolites released after exposure to monosodium urate crystals, which may contribute to the pathogenesis of crystal-provoked synovitides.
Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers.
- M. Laviolette, J. Chang, D. Newcombe
- Biology, MedicineAmerican Review of Respiratory Disease
- 14 May 2015
Human pulmonary macrophages recovered from young cigarette smokers and from age- and sex-matched subjects who had never smoked were used to investigate arachidonic acid metabolism to find a cigarette-smoke-induced lesion in phospholipid hydrolysis or the mechanism regulating phospholIPid Hydrolysis seem most consistent with these findings.
Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.
- D. Newcombe, C. Ciosek, Y. Ishikawa, J. Fahey
- BiologyProceedings of the National Academy of Sciences…
- 1 August 1975
The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine.…
Glucocorticoid inhibition of zymosan-induced arachidonic acid release by rat alveolar macrophages.
- M. Peters-Golden, J. Bathon, R. Flores, F. Hirata, D. Newcombe
- Biology, MedicineAmerican Review of Respiratory Disease
- 1 November 1984
The time course suggests a response dependent on newprotein synthesis, and the increased concentration of the phospholipase-inhibitory protein, lipomodulin, in steroid-treated cultures is putative evidence of new protein synthesis.
Hydrocortisone inhibition of the bradykinin activation of human synovial fibroblasts.
- D. Newcombe, J. Fahey, Y. Ishikawa
- Biology, MedicineProstaglandins
- 1 February 1977
The effect of anti-inflammatory agents on human synovial fibroblast prostaglandin synthetase.
- D. Newcombe, Y. Ishikawa
- Biology, MedicineProstaglandins
- 1 November 1976
Indomethacin potentiates PGE1 stimulated cyclic AMP accumulation in human synoviocytes
- C. Ciosek, R. Ortel, N. Thanassi, D. Newcombe
- Medicine, BiologyNature
- 13 September 1974
The capacity of the nonsteroidal anti-inflammatory agents, aspirin and indo-methacin (IM), to inhibit the synthesis of certain prostaglandins emphasises the potential importance of this hormone system in the pathogenesis and treatment of inflammatory arthritis.
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