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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed in many cancers and contribute to tumourExpand
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Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis
Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated byExpand
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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-xL (ref. 2). The structuresExpand
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Rationale for Bcl‐XL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
The three‐dimensional structure of the anti‐apoptotic protein Bcl‐XL complexed to a 25‐residue peptide from the death promoting region of Bad was determined using NMR spectroscopy. Although theExpand
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Solution structure of the antiapoptotic protein bcl-2
  • A. Petros, A. Medek, +6 authors S. Fesik
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 27 February 2001
The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined byExpand
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Solution structure of human survivin and its binding interface with Smac/Diablo.
NMR studies of the antiapoptotic protein survivin have been used to determine the homodimer interface of the protein in solution and to identify residues of the protein that interact withExpand
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Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.
The antiapoptotic proteins Bcl-x(L) and Bcl-2 play key roles in the maintenance of normal cellular homeostasis. However, their overexpression can lead to oncogenic transformation and is responsibleExpand
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Discovery of a novel small molecule binding site of human survivin.
Survivin is one of the most tumor-specific genes in the human genome and is an attractive target for cancer therapy. However, small-molecule ligands for survivin have not yet been described. Thus, anExpand
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A Surface Groove Essential for Viral Bcl-2 Function During Chronic Infection In Vivo
Antiapoptotic Bcl-2 family proteins inhibit apoptosis in cultured cells by binding BH3 domains of proapoptotic Bcl-2 family members via a hydrophobic BH3 binding groove on the protein surface. WeExpand
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Solution structure of the ets domain of Fli-1 when bound to DNA
Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of humanExpand
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