Share This Author
The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
Analyses of the Chlamydomonas genome advance the understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
The tomato genome sequence provides insights into fleshy fruit evolution
A high-quality genome sequence of domesticated tomato is presented, a draft sequence of its closest wild relative, Solanum pimpinellifolium, is compared, and the two tomato genomes are compared to each other and to the potato genome.
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
This revision supersedes the four previous updates in which a nomenclature system, based on divergent evolution of the P450 superfamily has been described and is similar to that proposed in the previous updates.
The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants
This comparison reveals genomic changes concomitant with the evolutionary movement to land, including a general increase in gene family complexity; loss of genes associated with aquatic environments; acquisition of genes for tolerating terrestrial stresses; and the development of the auxin and abscisic acid signaling pathways for coordinating multicellular growth and dehydration response.
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
The cytochrome P450 (CYP) gene superfamily is summarized and complete identification of all pseudogene sequences is likely to be clinically important, because some of these highly similar exons can interfere with PCR-based genotyping assays.
The Cytochrome P450 Homepage
- D. Nelson
- BiologyHuman Genomics
- 1 October 2009
The Cytochrome P450 Homepage is a universal resource for nomenclature and sequence information on CYP genes and conforms to an evolutionary scheme such that members of CYP families and subfamilies share common ancestors.
The Ectocarpus genome and the independent evolution of multicellularity in brown algae
The Ectocarpus genome sequence represents an important step towards developing this organism as a model species, providing the possibility to combine genomic and genetic approaches to explore these and other aspects of brown algal biology further.
The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus)
Papaya offers numerous advantages as a system for fruit-tree functional genomics, and this draft genome sequence provides the foundation for revealing the basis of Carica’s distinguishing morpho-physiological, medicinal and nutritional properties.
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
The likelihood that this ancient gene superfamily has existed for more than 3.5 billion years, and that the rate of P450 gene evolution appears to be quite nonlinear, is discussed.
Cytochrome P450 and the individuality of species.
- D. Nelson
- BiologyArchives of biochemistry and biophysics
- 1 September 1999
The biosynthesis of cholesterol in bacteria is discussed in relation to CYP51 as a lanosterol 14 alpha-demethylase, which may have been the first eukaryotic P450.