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CD133, a novel marker for human prostatic epithelial stem cells.
- Gavin D. Richardson, C. Robson, S. Lang, D. Neal, N. Maitland, A. Collins
- Medicine, Biology
- Journal of cell science
- 15 July 2004
Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia.… Expand
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
The androgen receptor (AR) is a key regulator of prostate growth and the principal drug target for the treatment of prostate cancer. Previous studies have mapped AR targets and identified some… Expand
The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man.
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We present a comprehensive analysis of AR binding sites in human… Expand
Multiple newly identified loci associated with prostate cancer susceptibility
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To… Expand
Screening for prostate cancer.
troversial public health issues in urology. The natural aging of the population and the continued and widespread use of improved diagnostic tests, such as serum prostate-specific antigen (PSA), are… Expand
The Evolutionary History of Lethal Metastatic Prostate Cancer
Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of… Expand
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
- Masanori Yoshimatsu, G. Toyokawa, +9 authors R. Hamamoto
- Medicine, Biology
- International journal of cancer
- 1 February 2011
Protein arginine methylation is a novel post‐translational modification regulating a diversity of cellular processes, including histone functions, but the roles of protein arginine methyltransferases… Expand
Multiple loci on 8q24 associated with prostate cancer susceptibility
- Ali Amin Al Olama, Z. Kote-Jarai, +32 authors D. Easton
- Biology, Medicine
- Nature Genetics
- 1 October 2009
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504… Expand
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and… Expand
Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression.
A major impediment to our understanding of the biology of stem cells is the inability to distinguish them from their differentiating progeny. We made use of the known association of stem cells with… Expand