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Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey
- N. Jenkinson, D. Nandi, R. Miall, J. Stein, T. Aziz
- Medicine
- Neuroreport
- 3 December 2004
We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed… Expand
Globus pallidus internus deep brain stimulation for dystonic conditions: A prospective audit
- J. Yianni, P. Bain, +7 authors T. Aziz
- Medicine
- Movement disorders : official journal of the…
- 1 April 2003
In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured target in the treatment of patients… Expand
Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus.
- D. Nandi, T. Aziz, Nir Giladi, J. Winter, J. Stein
- Psychology, Medicine
- Brain : a journal of neurology
- 1 November 2002
Recent studies, mainly in animals, have shown that the pedunculopontine nucleus (PPN) in the upper brainstem has extensive connections with several motor centres in the CNS. This structure has also… Expand
Deep brain stimulation: indications and evidence
- E. Pereira, A. Green, D. Nandi, T. Aziz
- Medicine
- Expert review of medical devices
- 1 September 2007
Deep brain stimulation is a minimally invasive targeted neurosurgical intervention that enables structures deep in the brain to be stimulated electrically by an implanted pacemaker. It has become the… Expand
Electrophysiological confirmation of the zona incerta as a target for surgical treatment of disabling involuntary arm movements in multiple sclerosis: use of local field potentials
Lesioning or chronic deep brain stimulation (DBS) of the nucleus ventralis intermedius results in abolition of tremor in the contralateral limbs in Parkinson's disease (PD) and also in essential… Expand
Deep brain stimulation of the pedunculopontine region in the normal non-human primate
Lesions in the pedunculopontine nucleus (PPN) cause akinesia. The PPN degenerates in Parkinson's disease. Stimulation of the PPN region induces stepping movements in rats and cats. These findings… Expand
Thalamotomy versus thalamic stimulation for multiple sclerosis tremor
Disabling intractable tremor occurs frequently in patients with multiple sclerosis (MS). There is currently no effective medical treatment available, and the results of surgical intervention have… Expand
Application of vibrational microspectroscopy to biology and medicine
- B. Singh, R. Gautam, +7 authors S. Umapathy
- Chemistry
- 25 January 2012
Vibrational microspectroscopic (Raman and infrared (IR)) techniques are rapidly emerging as effective tools to probe the basic processes of life. This review mainly focuses on the applications of… Expand
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Pedunculopontine stimulation from primate to patient
- E. A. Pereira, D. Nandi, N. Jenkinson, J. Stein, A. Green, T. Aziz
- Psychology, Medicine
- Journal of Neural Transmission
- 30 March 2011
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson’s disease and… Expand
Post‐operative progress of dystonia patients following globus pallidus internus deep brain stimulation
In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured intervention for patients with… Expand