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The epileptogenic zone: general principles.
Auteur(s) : Hans O Luders, Imad Najm, Dileep Nair, Peter Widdess-Walsh, William Bingman Epilepsy Center, Cleveland Clinic Foundation, Cleveland, USA Sir Victor Horsley, a British neurosurgeon,Expand
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Chronic Enhancement of the Intrinsic Growth Capacity of Sensory Neurons Combined with the Degradation of Inhibitory Proteoglycans Allows Functional Regeneration of Sensory Axons through the Dorsal
Peripherally conditioned sensory neurons have an increased capacity to regenerate their central processes. However, even conditioned axons struggle in the presence of a hostile CNS environment. WeExpand
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Focal Cortical Dysplasias in Eloquent Cortex: Functional Characteristics and Correlation with MRI and Histopathologic Changes
Summary:  Purpose: Focal cortical dysplasia (CD) is increasingly recognized as a common pathologic substrate of medically intractable epilepsy. As these lesions are often localized in the frontalExpand
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Epileptogenicity of Focal Malformations Due to Abnormal Cortical Development: Direct Electrocorticographic–Histopathologic Correlations
Summary:  Purpose: Malformations due to abnormal cortical development (MCDs) are common pathologic substrates of medically intractable epilepsy. The in situ epileptogenicity of these lesions as wellExpand
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Accentuated cortico-cortical evoked potentials in neocortical epilepsy in areas of ictal onset
ObjectiveTo determine whether patients with neocortical epilepsy show evidence for increased excitability measured by cortico-cortical evoked potentials (CCEPs) in ictal-onset regions.MethodsInExpand
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EEG and evoked potential recording from the subthalamic nucleus for deep brain stimulation of intractable epilepsy
OBJECTIVES The substantia nigra in the animal model has been implicated in the control of epilepsy. The substantia nigra pars reticulata (SNpr) receives afferents from the subthalamic nucleus (STN),Expand
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LONG‐TERM SEIZURE OUTCOME IN REOPERATION AFTER FAILURE OF EPILEPSY SURGERY
OBJECTIVETreatment of patients who fail epilepsy surgery is problematic. Selected patients may be candidates for further surgery, potentially leading to a significant decrease in the frequency andExpand
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Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy
In the last decade, single pulse electrical stimulation (SPES) has been used as an investigational tool in the field of epilepsy surgery. Direct cortical stimulation applied at a frequency of ∼1HzExpand
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Long‐term seizure outcome after resective surgery in patients evaluated with intracranial electrodes
Purpose:  Despite advances in “noninvasive” localization techniques, many patients with medically intractable epilepsy require the placement of subdural (subdural grid electrode, SDE) and/or depthExpand
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Cortical excitability varies upon ictal onset patterns in neocortical epilepsy: A cortico-cortical evoked potential study
OBJECTIVE To better understand pathological neuronal excitation in epilepsy by comparing cortico-cortical evoked potential (CCEP) responses in regions with different ictal onset patterns: focalExpand
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