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The role of the ascending 5-hydroxytryptaminergic pathways in timing behaviour: further observations with the interval bisection task
TLDR
It is proposed that rats may attain accurate timing under the interval bisection task by moving from one lever to the other during stimulus presentation; this movement may be facilitated by destruction of the 5HTergic pathways. Expand
Effects of desipramine and fluvoxamine on timing behaviour investigated with the fixed-interval peak procedure and the interval bisection task
TLDR
The failure of desipramine and fluvoxamine to increase the time to peak response rate or the bisection point at doses that significantly altered operant response rate suggests that the effect of these drugs on IRT schedule performance is unlikely to reflect an interaction with timing processes. Expand
Discriminative stimulus properties of amphetamine in a conditioned taste aversion paradigm
TLDR
The present results suggest the usefulness of the conditioned taste aversion procedure to train subjects in drug discrimination. Expand
Effects of indorenate on food intake: a comparison with fenfluramine and amphetamine
TLDR
The present results suggest the participation of serotoninergic, but not dopaminergic mechanisms, in the decrease in food intake produced by indorenate. Expand
Effect of destruction of the 5-hydroxytryptaminergic pathways on behavioural timing and “switching” in a free-operant psychophysical procedure
TLDR
The results confirm previous findings that behaviour in timing schedules is sensitive to destruction of the central 5HTergic pathways, and suggest that these pathways may contribute to the inhibitory regulation of switching between behavioural states. Expand
Temporal gradient of the discriminative stimulus properties of indorenate.
TLDR
This study, using adrug discrimination procedure, determined if the stimulus properties of INDO have a temporal course similar to their effects on 5-HT turnover. Expand
Effect of destruction of the 5-hydroxytryptaminergic pathways on the acquisition of temporal discrimination and memory for duration in a delayed conditional discrimination task
TLDR
The levels of 5HT and 5-hydroxyindoleacetic acid were reduced in the brains of the lesioned rats, but the levels of noradrenaline and dopamine were not altered. Expand
Retarded acquisition of a temporal discrimination following destruction of noradrenergic neurones by systemic treatment with DSP4
TLDR
The results indicate that noradrenaline depletion induced by DSP4 retarded the acquisition of temporal discrimination, but did not impair steady-state discriminative precision. Expand
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