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Structure-Function Relationships of C-Reactive Protein in Bacterial Infection
Non-native CRP is protective against both early stage and late stage infections, and it is quite possible that CRP functions as a general anti-bacterial molecule. Expand
Functional Transformation of C-reactive Protein by Hydrogen Peroxide*
It is hypothesized that one of the functions of CRP at sites of inflammation is to sense the inflammatory microenvironment, change its own structure in response but remain pentameric, and then bind to pathogenic proteins deposited at those sites. Expand
Engineered C-reactive protein with improved protective action against pneumococcal infection
The anti-pneumococcal function of native C-reactive protein (CRP) involves the binding of CRP to phosphocholine molecules present on Streptococcus pneumoniae and subsequent activation of theExpand
Purification of recombinant C-reactive protein mutants.
The methods used to purify pentameric recombinant wild-type and mutant CRP expressed in and secreted by mammalian cells are reported. Expand
Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal Infection
The hypothesis that complement activation by phosphocholine-complexed CRP is an antipneumococcal effector function was supported and it can be concluded that complementactivation by phospholipid complex is indeed essential for CRP-mediated protection of mice against pneumococcal infection. Expand
Treatment of Pneumococcal Infection by Using Engineered Human C-Reactive Protein in a Mouse Model
It is suggested that pre-modified CRP, such as E-CRP, is therapeutically beneficial to decrease bacteremia in pneumococcal infection and a model for the mechanism of action of CRP is proposed. Expand
C-Reactive Protein-Based Strategy to Reduce Antibiotic Dosing for the Treatment of Pneumococcal Infection
A mouse model of pneumococcal infection in which both E-CRP and clarithromycin, when used alone, provided minimal but equal protection against infection is established, providing an example of cooperation between the innate immune system and molecules that prevent multiplication of bacteria. Expand