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Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse
During site-specific DNA recombination, which brings about genetic rearrangement in processes such as viral integration and excision and chromosomal segregation, recombinase enzymes recognizeExpand
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Structure of the Holliday junction intermediate in Cre–loxP site‐specific recombination
We have determined the X‐ray crystal structures of two DNA Holliday junctions (HJs) bound by Cre recombinase. The HJ is a four‐way branched structure that occurs as an intermediate in geneticExpand
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Asymmetric DNA bending in the Cre-loxP site-specific recombination synapse.
Cre recombinase catalyzes site-specific recombination between two 34-bp loxP sites in a variety of DNA substrates. At the start of the recombination pathway, the loxP sites are each bound by twoExpand
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A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra.
Similarities between Mycobacterium tuberculosis phoP-phoR mutants and the attenuated laboratory strain M. tuberculosis H37Ra in terms of morphological and cytochemical properties, lipid content, geneExpand
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Identification of DNA Binding Motifs of the Mycobacterium tuberculosis PhoP/PhoR Two-Component Signal Transduction System
Background The Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system controls the expression of about 2% of the genome and plays a major role in pathogenicity. However, itsExpand
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Identification of key structural determinants of the IntI1 integron integrase that influence attC × attI1 recombination efficiency
The integron platform codes for an integrase (IntI) from the tyrosine family of recombinases that mediates recombination between a proximal double-strand recombination site, attI and a single-strandExpand
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Structure and mechanism in site-specific recombination.
Three-dimensional structural information on the integrase family of site-specific recombinases has only recently become available, with the crystal structures of catalytic domains, full-lengthExpand
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The relaxed requirements of the integron cleavage site allow predictable changes in integron target specificity
Integrons are able to incorporate exogenous genes embedded in mobile cassettes, by a site-specific recombination mechanism. Gene cassettes are collected at the attI site, via an integrase mediatedExpand
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Initial Characterization of the Pf-Int Recombinase from the Malaria Parasite Plasmodium falciparum
Background Genetic variation is an essential means of evolution and adaptation in many organisms in response to environmental change. Certain DNA alterations can be carried out by site-specificExpand
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Thio- and Seleno-Dioxaphosphorinane-Constrained Dinucleotides (D-CNA), Synthesis and Conformational Study
Thio- and seleno-α,β- and α,β,γ-CNA (Constrained Nucleic Acid) dinucleotides in which two or three torsional angles of the sugar/phosphate backbone are controlled within a dioxaphosphorinaneExpand
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