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Topical nonsteroidal antipsoriatic agents. 1. 1,2,3,4-Tetraoxygenated naphthalene derivatives.
Lonapalene (11a) is currently in clinical development as a topically applied nonsteroidal antipsoriatic agent and net lipophilicity, hydrolytic stability, and ring substitution play significant roles in determining the observed in vivo activity. Expand
Analogs of adenosine 3',5'-cyclic phosphate. II. Synthesis and enzymatic activity of derivatives of 1,N6-ethenoadenosine 3',5'-cyclic phosphate.
While no derivative proved to be more active than adenosine 3′,5′-cyclic phosphate itself using the enzyme from rabbit muscle, a wide spectrum of activities was found using that from calf brain. Expand
Synthesis of three potential inhibitors of leukotriene biosynthesis.
Two compounds are apparently stimulated, while 3 inhibited, the activity of lipoxygenase from intact human polymorphonuclear leukocytes in vitro when stimulated with Ca2+ and calcium ionophore A23187 in the presence of BSA and arachidonic acid. Expand
New bis-N9-(methylphenylmethyl)purine derivatives: synthesis and antitumor activity.
A series of ortho-, meta- and para-bis-N9-(methylphenylmethyl)purine derivatives 4-15 were obtained by two-step synthesis from various substituted chloropurines with alpha,alpha'-dichloroxylenes, and in particular compound 8 exhibited high sensitivity in leukemia cell lines and compounds 5, 8 and 11 exhibited consistent highensitivity in many breast cancer cell lines. Expand
9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase.
New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 andExpand
N9- and N7-(Chloromethyl Phenymethyl)Chloropurine Derivatives from α, α'-Dichloroxylenes: Synthesis and Anticancer Activity
A series of ortho- meta- and para-N9-[(chloromethylphenyl)methyl]chloropurines 4-12 and N7-[(chloromethylphenyl)methyl]chloropurines 13-21 were obtained by the reaction of various substitutedExpand