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A spinal vasopressinergic mechanism mediates hyperosmolality‐induced sympathoexcitation
TLDR
The results suggest that a physiological hyperosmotic stimulus produces sympathetically mediated hypertension in conscious rats and demonstrate the importance of vasopressin acting on spinal V1a receptors for mediating sympathoexcitatory response to acute salt loading.
Adenoviral vector demonstrates that angiotensin II‐induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat
TLDR
It is suggested that ANGII activates eNOS located in either neurones and/or endothelial cells to release NO, which acts selectively to depress the baroreflex.
Microarray Analysis Reveals Interleukin-6 as a Novel Secretory Product of the Hypothalamo-neurohypophyseal System*
TLDR
It is suggested that IL-6 takes the samesecretory pathway as VP and is secreted from the posterior pituitary following a physiological stimulus.
A comprehensive description of the transcriptome of the hypothalamoneurohypophyseal system in euhydrated and dehydrated rats
TLDR
Microarrays are used to comprehensively catalog the genes expressed in the PVN, the SON and the neurointermediate lobe of the pituitary gland of control and dehydrated rats to suggest that these differentially expressed genes represent candidate regulators and effectors of HNS activity and remodeling.
Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats
TLDR
The results demonstrate that Hey‐Presto allows a fully automated, reliable, fast and comprehensive evaluation of cardiovascular autonomic function based on chronic measurements of BP in rats and confirmed its versatility by demonstrating its application to man.
Osmoregulation Requires Brain Expression of the Renal Na-K-2Cl Cotransporter NKCC2
TLDR
Na-K-2Cl cotransporter 2 expression in the brain hypothalamo-neurohypophyseal system (HNS), wherein upregulation follows osmotic stress is shown, wherein NKCC2-dependent brain mechanisms that regulate osmosis stability are disrupted by loop diuretics in rats.
Junctional Adhesion Molecule-1 Is Upregulated in Spontaneously Hypertensive Rats: Evidence for a Prohypertensive Role Within the Brain Stem
TLDR
The data suggest that JAM-1 expression in the spontaneously hypertensive rat is upregulated throughout the body compared with the WKY rat and that this is not secondary to the hypertension.
Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene
TLDR
Inhibition of autophagy or lysosomal protein degradation, while having no effect on Ad‐VCAT‐expressing cells, significantly increased apoptotic cell death following Ad‐ VCAT‐Cys67stop expression, suggesting that activation of autophile by the stress of the expression of an adFNDI mutant protein is a prosurvival mechanism.
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