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The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker.
The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and mechanistic function have remained somewhat elusive ever since it was first reported in 1970 as a viralExpand
Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity
Dengue virus NS1 protein induces inflammatory responses via TLR4 and disrupts endothelial cell monolayer integrity. A leak in the dike Everyone knows how mosquitos can wreck an end-of-summer picnic.Expand
Clinical and Laboratory Diagnosis of Dengue Virus Infection
Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that dengue virusExpand
Surface modified microprojection arrays for the selective extraction of the dengue virus NS1 protein as a marker for disease.
While advances in assay chemistry and detection continue to improve molecular diagnostics technology, blood samples are still collected using the 150-year-old needle/syringe method. Surface modifiedExpand
SwarmPS: rapid, semi-automated single particle selection software.
We present Swarm(PS), a feature rich GUI based software package to manage large scale, semi-automated particle picking projects. Expand
Functional anti-polysaccharide IgG titres induced by unadjuvanted pneumococcal-conjugate vaccine when delivered by microprojection-based skin patch.
Adequate access to effective and affordable vaccines is essential for the prevention of mortality due to infectious disease. Pneumonia--a consequence of Streptococcus pneumoniae infection--is theExpand
Structure of the dengue virus glycoprotein non-structural protein 1 by electron microscopy and single-particle analysis.
The flavivirus non-structural protein 1 (NS1) is a glycoprotein that is secreted as a soluble hexameric complex during the course of natural infection. Growing evidence indicates that this secretedExpand
Surface modifications of microprojection arrays for improved biomarker capture in the skin of live mice.
New technologies are needed to translate biomarker discovery research into simple, inexpensive, and effective molecular diagnostic assays for use by clinicians or patients to guide and monitorExpand
Surface modification and characterization of polycarbonate microdevices for capture of circulating biomarkers, both in vitro and in vivo.
Herein, we report the fabrication, characterization, and testing of a polymer microprojection array, for the direct and selective capture of circulating biomarkers from the skin of live mice. First,Expand
Capture of the circulating Plasmodium falciparum biomarker HRP2 in a multiplexed format, via a wearable skin patch.
Herein we demonstrate the use of a wearable device that can selectively capture two distinct circulating protein biomarkers (recombinant P. falciparum rPfHRP2 and total IgG) from the intradermalExpand