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Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.
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Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene
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Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage.
TLDR
A dynamic antagonistic relationship between CUGBP2 and COX-2 is demonstrated and it is suggested that lipopolysaccharide-mediated inhibition of CU GBP2 is a PG-dependent mechanism.
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Novel Role for RNA-binding Protein CUGBP2 in Mammalian RNA Editing
TLDR
Data suggest that CUGBP2 plays a role in apoB mRNA editing by forming a regulatory complex with the three components of the minimal editing enzyme, apobec-1, ACF, and apOB RNA.
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ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing.
TLDR
The data suggest that ARCD-1 is a novel cytidine deaminase that interacts with apobec-1 and ACF to inhibit apoB mRNA editing, possibly through interaction with other protein components of the apo B RNA editing holoenzyme.
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Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression.
TLDR
Lipopolysaccharide increases intestinal stem cell survival through apobec-1-mediated regulation of cyclooxygenase-2 messenger RNA stability.
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C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.
TLDR
The hypothesis that C-->U RNA editing of the NF1 transcript occurs both in a subset of PNSTs and in an alternatively spliced form containing a downstream exon, presumably an optimal configuration for enzymatic deamination by apobec-1 is supported.
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CUGBP2 Plays a Critical Role in Apoptosis of Breast Cancer Cells in Response to Genotoxic Injury
TLDR
It is determined that expression of both COX‐2 mRNA and CUGBP2 mRNA are induced in MCF‐7 cells, a breast cancer cell line, following exposure to 12 Gy γ‐irradiation, and silencer RNA (siRNA)‐mediated inhibition of CU GBP2 reversed the block in COX-2 protein expression.
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Thyroid hormone regulates hepatic triglyceride mobilization and apolipoprotein B messenger ribonucleic Acid editing in a murine model of congenital hypothyroidism.
TLDR
It is demonstrated that thyroid hormone modulates murine hepatic lipoprotein metabolism in association with tissue-specific effects on apoB RNA editing mediated through alterations in ACF gene expression.
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Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs.
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